2. Gene
  3. Sqstm1 - sequestosome 1 Gene

Sqstm1 - sequestosome 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Osi; ZIP; ZIP3

Gene ID: 113894 | Gene type: protein coding

About Sqstm1

Summary

Enables identical protein binding activity and protein kinase C binding activity. Involved in positive regulation of protein phosphorylation and response to ischemia. Located in Lewy body and mitochondrion. Biomarker of glaucoma and hypertension. Human ortholog(s) of this gene implicated in GNE myopathy; Paget's disease of bone; and frontotemporal dementia and/or amyotrophic lateral sclerosis-3. Orthologous to human SQSTM1 (sequestosome 1). [provided by Alliance of Genome Resources, Apr 2022]

Sqstm1 Products(5)

mRNA Protein Name
NM_001393884.1 NP_001380813.1 sequestosome-1 isoform 3
NM_001393885.1 NP_001380814.1 sequestosome-1 isoform 4
NM_001393886.1 NP_001380815.1 sequestosome-1 isoform 5
NM_175843.5 NP_787037.2 sequestosome-1 isoform 1
NM_181550.2 NP_853528.2 sequestosome-1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
10477520 RGD
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
10477520 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
23782269 RGD
Cellular Component GO Annotation Evidence Reference Source
located in Lewy body IDA
IDA: Inferred from direct assay
15158159 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
28231469 RGD
is active in synapse IDA
IDA: Inferred from direct assay
28231469 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sequestosome-1

PKC-zeta-interacting protein

oxidative stress induced

protein kinase C-zeta-interacting protein

ubiquitin-binding protein p62

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112698 CA-5f 99.14% Unkown
HY-117469 Triptohypol C 95.44% Unkown
HY-152100 CUR5g Inhibitor 98.69% Unkown
HY-169387 YT 6-2-PEG3-C2-NH2 Control / Unkown
HY-RS13745 SQSTM1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-169385 ATC-324 Degrader / Unkown
HY-169386 YT 6-2 analog-1 Control / Unkown
HY-169388 YT 6-2 Control / Unkown
HY-RS17351 Sqstm1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23805 Sqstm1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sqstm1 NCBI NCBI:8878