Abl2 - v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) Gene

Mus musculus

Also known as Arg; Abll

Gene ID: 11352 | Gene type: protein coding

About Abl2

Summary

Enables magnesium ion binding activity; manganese ion binding activity; and protein tyrosine kinase activity. Involved in actin Cytoskeleton organization; peptidyl-tyrosine phosphorylation; and synapse maturation. Acts upstream of or within several processes, including nervous system development; regulation of signal transduction; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in several cellular components, including dendritic spine; lamellipodium; and phagocytic cup. Is active in glutamatergic synapse. Is expressed in several structures, including brain; diaphragm; hindlimb long bone; liver; and seminiferous cord. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Abl2 Products(2)

mRNA	Protein	Name
NM_001136104.1	NP_001129576.1	tyrosine-protein kinase ABL2 isoform a
NM_009595.3	NP_033725.2	tyrosine-protein kinase ABL2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables magnesium ion binding	IDA IDA: Inferred from direct assay	12748290	MGI
enables manganese ion binding	IDA IDA: Inferred from direct assay	12748290	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19414610	MGI
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	12748290	MGI
enables protein tyrosine kinase activity	IGI IGI: Inferred from genetic interaction	18827006	MGI
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	15084284	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Bergmann glial cell differentiation	IGI IGI: Inferred from genetic interaction	20980600	MGI
acts upstream of or within DN4 thymocyte differentiation	IGI IGI: Inferred from genetic interaction	18025176	MGI
acts upstream of Rho protein signal transduction	IGI IGI: Inferred from genetic interaction	23595732	MGI
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	11752434	MGI
acts upstream of or within actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	9883720	MGI
acts upstream of or within actin filament bundle assembly	IDA IDA: Inferred from direct assay	11752434	MGI
acts upstream of or within actin filament organization	IDA IDA: Inferred from direct assay	11752434	MGI
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	9883720	MGI
acts upstream of or within aggressive behavior	IMP IMP: Inferred from mutant phenotype	9883720	MGI
acts upstream of or within alpha-beta T cell differentiation	IGI IGI: Inferred from genetic interaction	18025176	MGI
acts upstream of or within auditory behavior	IMP IMP: Inferred from mutant phenotype	9883720	MGI
acts upstream of canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	18025176	MGI
acts upstream of cell-cell adhesion	IGI IGI: Inferred from genetic interaction	24367707	MGI
acts upstream of or within cerebellum morphogenesis	IGI IGI: Inferred from genetic interaction	20980600	MGI
acts upstream of or within circulatory system development	IGI IGI: Inferred from genetic interaction	9883720	MGI
acts upstream of or within dendrite morphogenesis	IGI IGI: Inferred from genetic interaction	22357865	MGI
acts upstream of or within dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	23365224	MGI
acts upstream of or within dendritic spine maintenance	IGI IGI: Inferred from genetic interaction	23365224	MGI
acts upstream of or within dendritic spine maintenance	IMP IMP: Inferred from mutant phenotype	23365224	MGI
acts upstream of or within epidermal growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	18827006	MGI
acts upstream of or within establishment of localization in cell	IGI IGI: Inferred from genetic interaction	23100514	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	22665498	MGI
acts upstream of or within exploration behavior	IGI IGI: Inferred from genetic interaction	23595732	MGI
acts upstream of or within learning	IMP IMP: Inferred from mutant phenotype	19805386	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	9883720	MGI
acts upstream of or within negative regulation of Rho protein signal transduction	IGI IGI: Inferred from genetic interaction	15084284	MGI
acts upstream of or within negative regulation of cell-cell adhesion	IGI IGI: Inferred from genetic interaction	24367707	MGI
acts upstream of or within negative regulation of endothelial cell apoptotic process	IGI IGI: Inferred from genetic interaction	23840065	MGI
acts upstream of or within neural tube closure	IGI IGI: Inferred from genetic interaction	9883720	MGI
acts upstream of or within neuroepithelial cell differentiation	IGI IGI: Inferred from genetic interaction	9883720	MGI
acts upstream of or within neuromuscular process controlling balance	IGI IGI: Inferred from genetic interaction	20980600	MGI
acts upstream of or within neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	9883720	MGI
acts upstream of or within neuron differentiation	IGI IGI: Inferred from genetic interaction	9883720	MGI
acts upstream of or within neuron remodeling	IMP IMP: Inferred from mutant phenotype	19805386	MGI
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	12748290	MGI
acts upstream of or within phagocytosis	IGI IGI: Inferred from genetic interaction	23100514	MGI
acts upstream of or within phagocytosis	IMP IMP: Inferred from mutant phenotype	22665498	MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	18827006	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	18827006	MGI
involved in positive regulation of T cell migration	IMP IMP: Inferred from mutant phenotype	22810897	MGI
acts upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway	IGI IGI: Inferred from genetic interaction	20837657	MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	18025176	MGI
involved in positive regulation of establishment of T cell polarity	IMP IMP: Inferred from mutant phenotype	22810897	MGI
acts upstream of or within positive regulation of interleukin-2 production	IGI IGI: Inferred from genetic interaction	18025176	MGI
acts upstream of or within positive regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	15084284	MGI
acts upstream of or within positive regulation of protein binding	IMP IMP: Inferred from mutant phenotype	15084284	MGI
acts upstream of or within positive regulation of type II interferon production	IGI IGI: Inferred from genetic interaction	18025176	MGI
acts upstream of or within post-embryonic development	IGI IGI: Inferred from genetic interaction	9883720	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	23365224	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12748290	MGI
acts upstream of or within regulation of extracellular matrix organization	IGI IGI: Inferred from genetic interaction	20980600	MGI
acts upstream of or within reproductive process	IMP IMP: Inferred from mutant phenotype	9883720	MGI
acts upstream of or within substrate-dependent cell migration, cell extension	IGI IGI: Inferred from genetic interaction	19414610	MGI
involved in synapse maturation	IDA IDA: Inferred from direct assay	27335408	MGI
involved in synapse maturation	IMP IMP: Inferred from mutant phenotype	27335408	MGI
acts upstream of or within visual learning	IGI IGI: Inferred from genetic interaction	22357865	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	11752434	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	23365224	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23365224	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23365224	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	19414610	MGI
located in phagocytic cup	IDA IDA: Inferred from direct assay	23100514	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	23365224	MGI
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	23365224	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tyrosine-protein kinase ABL2

Abelson tyrosine-protein kinase 2	Abelson-related gene protein
abelson murine leukemia viral oncogene homolog 2	tyrosine kinase ARG
tyrosine-protein kinase ARG	v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-148794	Risvodetinib	Inhibitor	99.21%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148063	DB0614		98.80%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-RS00105	ABL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18744	Abl2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25231	Abl2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abl2	NCBI	NCBI:27

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