Srsf1 - serine and arginine-rich splicing factor 1 Gene

Mus musculus

Also known as Asf; Sf2; Sfrs1; 1110054N12Rik; 5730507C05Rik; 6330415C05Rik

Gene ID: 110809 | Gene type: protein coding

About Srsf1

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding Other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Srsf1 Products(2)

mRNA	Protein	Name
NM_001078167.2	NP_001071635.1	serine/arginine-rich splicing factor 1 isoform 2
NM_173374.4	NP_775550.2	serine/arginine-rich splicing factor 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RS domain binding	IPI IPI: Inferred from physical interaction	15798186	MGI
enables mRNA binding	IMP IMP: Inferred from mutant phenotype	21822258	MGI
enables molecular function regulator activity	IDA IDA: Inferred from direct assay	21822258	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20477871	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within RNA splicing	IDA IDA: Inferred from direct assay	15798186	MGI
acts upstream of or within RNA splicing	IGI IGI: Inferred from genetic interaction	15652482	MGI
acts upstream of or within cardiac muscle contraction	IGI IGI: Inferred from genetic interaction	15652482	MGI
involved in cellular response to interleukin-17	IDA IDA: Inferred from direct assay	29563620	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	15652482	MGI
involved in interleukin-17-mediated signaling pathway	IDA IDA: Inferred from direct assay	21822258	MGI
involved in interleukin-17-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	21822258	MGI
involved in mRNA stabilization	IDA IDA: Inferred from direct assay	21822258	MGI
involved in mRNA stabilization	IMP IMP: Inferred from mutant phenotype	21822258	MGI
involved in protein localization to P-body	IDA IDA: Inferred from direct assay	29563620	MGI
involved in protein localization to nucleus	IDA IDA: Inferred from direct assay	29563620	MGI
involved in regulation of RNA splicing	IMP IMP: Inferred from mutant phenotype	28785060	MGI
involved in signal transduction involved in regulation of gene expression	IDA IDA: Inferred from direct assay	21822258	MGI
involved in signal transduction involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21822258	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear speck	IDA IDA: Inferred from direct assay	20729808	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15615787	MGI
is active in nucleus	IPI IPI: Inferred from physical interaction	29563620	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/arginine-rich splicing factor 1

ASF/SF2	pre-mRNA-splicing factor SRp30a
splicing factor, arginine/serine-rich 1 (ASF/SF2)

Srsf1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Srsf1	Q6PDM2	Polr2a	Mus musculus	P08775	Anti Tag CoIP	23663783
Intra	Srsf1	Q6PDM2	Traf5	Mus musculus	P70191	Anti Bait CoIP	21822258
Intra	Srsf1	Q6PDM2	Hexim1	Mus musculus	Q8R409	Anti Tag CoIP	23663783

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117661	SPHINX31	Inhibitor	98.84%	Unkown
HY-170935	SRSF1-IN-1	Inhibitor	/	Unkown
HY-RS13790	SRSF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17174	Srsf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23624	Srsf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Srsf1	NCBI	NCBI:6426

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