2. Gene
  3. Atxn3 - ataxin 3 Gene

Atxn3 - ataxin 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Mjd; ATX3; MJD1; Sca3; ataxin-3; 2210008M02Rik

Gene ID: 110616 | Gene type: protein coding

About Atxn3

Summary

Enables thiol-dependent Deubiquitinase and ubiquitin protein Ligase binding activity. Involved in cellular response to misfolded protein and proteolysis. Acts upstream of or within several processes, including cellular response to heat; exploration behavior; and ubiquitin-dependent protein catabolic process. Located in mitochondrial matrix; mitochondrial membrane; and nuclear inclusion body. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; musculature; and testis. Human ortholog(s) of this gene implicated in Machado-Joseph disease. Orthologous to several human genes including ATXN3 (ataxin 3). [provided by Alliance of Genome Resources, Apr 2022]

Atxn3 Products(2)

mRNA Protein Name
NM_001167914.1 NP_001161386.1 ataxin-3 isoform 2
NM_029705.3 NP_083981.2 ataxin-3 isoform 1
Protein Preferred Names Protein Names

ataxin-3

Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) homolog

machado-Joseph disease protein 1 homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01258 ATXN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01259 ATXN3L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19985 Atxn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26489 Atxn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atxn3 NCBI NCBI:4287