BTG3 - BTG anti-proliferation factor 3 Gene

Homo sapiens

Also known as ANA; TOB5; TOFA; APRO4; TOB55; ANA/BTG3

Gene ID: 10950 | Gene type: protein coding

About BTG3

Cytogenetic location: 21q21.1 Genomic coordinates (GRCh38): 21:17,593,653-17,612,901 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 181 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 24.4), placenta (RPKM 23.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

BTG3 Products(2)

mRNA	Protein	Name
NM_001130914.2	NP_001124386.1	protein BTG3 isoform a
NM_006806.5	NP_006797.3	protein BTG3 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17690688	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	9632145	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9632145	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTG3 Protein Structure

BTG

0
100
200
252 a.a.

Protein Preferred Names

Protein Names

protein BTG3

B-cell translocation gene 3

Related Diseases

Diseases

Alias

Cataract 37

CTRCT37	Cca5
Cataract, Congenital, Cerulean Type, 5	Cataract 37, Autosomal Dominant
Congenital Cataract Cerulean Type 5

Enterokinase Deficiency

Enteropeptidase Deficiency	Congenital Enterokinase Deficiency
Congenital Enteropathy Due To Enteropeptidase Deficiency	Deficiency Of Enteropeptidase
ENTKD

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01664	BTG3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BTG3	VGNC	VGNC:70289
Mus musculus	BTG3	MGD	MGI:109532
Rattus norvegicus	BTG3	RGD	RGD:2226
Bos taurus	BTG3	VGNC	VGNC:26599
Felis catus	BTG3	VGNC	VGNC:60205
Canis familiaris	BTG3	VGNC	VGNC:38559

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