2. Gene
  3. Orai1 - ORAI calcium release-activated calcium modulator 1 Gene

Orai1 - ORAI calcium release-activated calcium modulator 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as orai-1; Tmem142a; D730049H07Rik

Gene ID: 109305 | Gene type: protein coding

About Orai1

Summary

Predicted to enable identical protein binding activity and store-operated Calcium Channel activity. Acts upstream of or within calcium ion import; mammary gland epithelium development; and store-operated calcium entry. Located in basolateral plasma membrane. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; reproductive system; respiratory system; and skin. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Orthologous to human ORAI1 (ORAI calcium release-activated calcium modulator 1). [provided by Alliance of Genome Resources, Apr 2022]

Orai1 Products(1)

mRNA Protein Name
NM_175423.3 NP_780632.1 calcium release-activated calcium channel protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17343823 MGI
enables store-operated calcium channel activity IMP
IMP: Inferred from mutant phenotype
31664108 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within calcium ion import IDA
IDA: Inferred from direct assay
23840669 MGI
involved in ion channel modulating, G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
31664108 MGI
involved in ligand-gated ion channel signaling pathway IMP
IMP: Inferred from mutant phenotype
31664108 MGI
acts upstream of or within mammary gland epithelium development IMP
IMP: Inferred from mutant phenotype
23840669 MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
31664108 MGI
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
31664108 MGI
acts upstream of or within store-operated calcium entry IGI
IGI: Inferred from genetic interaction
17343823 MGI
Cellular Component GO Annotation Evidence Reference Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
23840669 MGI
located in membrane IDA
IDA: Inferred from direct assay
17343823 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
17343823 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calcium release-activated calcium channel protein 1

calcium release-activated calcium channel 1

protein orai-1

transmembrane protein 142A

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-101942 Zegocractin Inhibitor 99.96% Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19408 Pyr10 Inhibitor 99.95% Unkown
HY-103310 MRS1845 Inhibitor 99.69% Unkown
HY-113618B RO2959 monohydrochloride Inhibitor 98.21% Unkown
HY-12521 GSK-5498A Inhibitor 99.94% Unkown
HY-113618A RO2959 hydrochloride Inhibitor / Unkown
HY-RS17989 Orai1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-103071 GSK-5503A Inhibitor / Unkown
HY-RS09822 ORAI1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24460 Orai1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990478 Anti-Orai1 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Orai1 NCBI NCBI:84876