Card11 - caspase recruitment domain family, member 11 Gene

Mus musculus

Also known as BIMP3; CARMA1; 0610008L17Rik; 2410011D02Rik

Gene ID: 108723 | Gene type: protein coding

About Card11

Summary

Predicted to enable CARD domain binding activity and protein self-association. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; and positive regulation of T cell receptor signaling pathway. Acts upstream of or within several processes, including lymphocyte differentiation; positive regulation of interleukin-2 production; and regulation of lymphocyte activation. Located in immunological synapse. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma; immunodeficiency 11A; and immunodeficiency 11B. Orthologous to human CARD11 (Caspase recruitment domain family member 11). [provided by Alliance of Genome Resources, Apr 2022]

Card11 Products(1)

mRNA	Protein	Name
NM_175362.2	NP_780571.2	caspase recruitment domain-containing protein 11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12356734	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell differentiation	IMP IMP: Inferred from mutant phenotype	12818158	MGI
acts upstream of B cell proliferation	IMP IMP: Inferred from mutant phenotype	12867038	MGI
acts upstream of or within B cell proliferation	IMP IMP: Inferred from mutant phenotype	12818158	MGI
acts upstream of CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	12867038	MGI
acts upstream of T cell activation	IMP IMP: Inferred from mutant phenotype	12867038	MGI
acts upstream of or within T cell activation	IMP IMP: Inferred from mutant phenotype	12818158	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	12818158	MGI
acts upstream of or within immunoglobulin production	IMP IMP: Inferred from mutant phenotype	12818158	MGI
acts upstream of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	12867038	MGI
acts upstream of or within interleukin-2 production	IMP IMP: Inferred from mutant phenotype	12818158	MGI
acts upstream of or within lymphocyte activation	IMP IMP: Inferred from mutant phenotype	12818158	MGI
acts upstream of or within positive regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	12867038	MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	12867038	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	12154356	MGI
acts upstream of or within positive regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	12867038	MGI
involved in positive regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12154356	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	12154356	MGI
acts upstream of or within positive regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	12867038	MGI
acts upstream of or within regulation of B cell differentiation	IMP IMP: Inferred from mutant phenotype	12867038	MGI
acts upstream of or within regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	12867038	MGI
acts upstream of or within regulation of immune response	IMP IMP: Inferred from mutant phenotype	12867038	MGI
acts upstream of or within signal transduction	IDA IDA: Inferred from direct assay	12356734	MGI
acts upstream of or within thymic T cell selection	IMP IMP: Inferred from mutant phenotype	12867038	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in immunological synapse	IDA IDA: Inferred from direct assay	23793062	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12867038	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

caspase recruitment domain-containing protein 11

CARD-containing MAGUK protein 1

carma 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-142648A	(R)-MLT-985	Inhibitor	/	Unkown
HY-174371	INNO-220		/	Unkown
HY-RS01916	CARD11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17847	Card11 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24315	Card11 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Card11	NCBI	NCBI:84433

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