2. Gene
  3. Shmt2 - serine hydroxymethyltransferase 2 (mitochondrial) Gene

Shmt2 - serine hydroxymethyltransferase 2 (mitochondrial) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as SHMT; 2700043D08Rik

Gene ID: 108037 | Gene type: protein coding

About Shmt2

Summary

Enables glycine hydroxymethyltransferase activity. Involved in regulation of mitochondrial translation; regulation of oxidative phosphorylation; and tetrahydrofolate interconversion. Located in nucleus. Is expressed in several structures, including brain; neural retina; placenta; skeleton; and submandibular gland primordium. Orthologous to human SHMT2 (serine hydroxymethyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Shmt2 Products(2)

mRNA Protein Name
NM_001252316.1 NP_001239245.1 serine hydroxymethyltransferase, mitochondrial isoform 2
NM_028230.4 NP_082506.1 serine hydroxymethyltransferase, mitochondrial isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables glycine hydroxymethyltransferase activity IGI
IGI: Inferred from genetic interaction
19513116 MGI
enables glycine hydroxymethyltransferase activity IMP
IMP: Inferred from mutant phenotype
19513116 MGI
Biological Process GO Annotation Evidence Reference Source
involved in regulation of aerobic respiration IMP
IMP: Inferred from mutant phenotype
29323231 MGI
involved in regulation of mitochondrial translation IMP
IMP: Inferred from mutant phenotype
29323231 MGI
involved in regulation of oxidative phosphorylation IMP
IMP: Inferred from mutant phenotype
29323231 MGI
involved in tetrahydrofolate interconversion IMP
IMP: Inferred from mutant phenotype
19513116 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in nucleus IDA
IDA: Inferred from direct assay
19513116 MGI
is active in nucleus IGI
IGI: Inferred from genetic interaction
19513116 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine hydroxymethyltransferase, mitochondrial

glycine hydroxymethyltransferase

serine methylase

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-129226 SHMT-IN-2 Inhibitor 99.60% Unkown
HY-134978 (Rac)-SHIN2 Inhibitor 99.40% Unkown
HY-148545 SHMT-IN-3 Inhibitor ≥98.0% Unkown
HY-RS12877 SHMT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17061 Shmt2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23505 Shmt2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Shmt2 NCBI NCBI:6472