2. Gene
  3. Celsr3 - cadherin, EGF LAG seven-pass G-type receptor 3 Gene

Celsr3 - cadherin, EGF LAG seven-pass G-type receptor 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Fmi1; Adgrc3; flamingo; mKIAA0812

Gene ID: 107934 | Gene type: protein coding

About Celsr3

Summary

Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in dopaminergic neuron axon guidance; planar cell polarity pathway involved in axon guidance; and serotonergic neuron axon guidance. Acts upstream of or within several processes, including cilium assembly; generation of neurons; and regulation of protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including central nervous system; embryo ectoderm; epiblast; peripheral nervous system; and retina. Orthologous to human CELSR3 (Cadherin EGF LAG seven-pass G-type receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Celsr3 Products(3)

mRNA Protein Name
NM_001359572.1 NP_001346501.1 cadherin EGF LAG seven-pass G-type receptor 3 isoform 1 precursor
NM_001359573.1 NP_001346502.1 cadherin EGF LAG seven-pass G-type receptor 3 isoform 2 precursor
NM_080437.3 NP_536685.2 cadherin EGF LAG seven-pass G-type receptor 3 isoform 3 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in Wnt signaling pathway, planar cell polarity pathway IMP
IMP: Inferred from mutant phenotype
21106844 MGI
acts upstream of or within axonal fasciculation IMP
IMP: Inferred from mutant phenotype
15778712 MGI
acts upstream of or within cilium assembly IGI
IGI: Inferred from genetic interaction
20473291 MGI
involved in dopaminergic neuron axon guidance IMP
IMP: Inferred from mutant phenotype
21106844 MGI
acts upstream of or within motor neuron migration IMP
IMP: Inferred from mutant phenotype
20631168 MGI
acts upstream of or within regulation of protein localization IGI
IGI: Inferred from genetic interaction
20473291 MGI
acts upstream of or within regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
24305805 MGI
involved in serotonergic neuron axon guidance IMP
IMP: Inferred from mutant phenotype
21106844 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
34407949 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
34407949 MGI
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
34407949 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cadherin EGF LAG seven-pass G-type receptor 3

cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-175232 GL64 / Unkown
HY-RS02467 CELSR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18305 Celsr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24783 Celsr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Celsr3 NCBI NCBI:1951