Jmjd6 - jumonji domain containing 6 Gene

Mus musculus

Also known as PSR; Ptdsr; PtdSerR; mKIAA0585; D11Ertd195e; 5730436I23Rik

Gene ID: 107817 | Gene type: protein coding

About Jmjd6

Summary

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein functions in differentiation of multiple tissues during development, and in anti-inflammatory cytokine signaling. It was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that this protein does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. [provided by RefSeq, Jul 2008]

Jmjd6 Products(2)

mRNA	Protein	Name
NM_001363363.1	NP_001350292.1	bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform 1
NM_033398.3	NP_203971.2	bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	21060799	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	21060799	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21300889	MGI
enables signaling receptor activity	IDA IDA: Inferred from direct assay	10811223	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	14715629	MGI
NOT acts upstream of or within apoptotic cell clearance	IMP IMP: Inferred from mutant phenotype	15345036	MGI
acts upstream of or within apoptotic cell clearance	IMP IMP: Inferred from mutant phenotype	14715629	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	15615595	MGI
acts upstream of or within cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	10811223	MGI
acts upstream of or within erythrocyte development	IMP IMP: Inferred from mutant phenotype	14715629	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	15615595	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	15345036	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	14645847	MGI
acts upstream of or within macrophage activation	IMP IMP: Inferred from mutant phenotype	15345036	MGI
involved in negative regulation of protein homooligomerization	IDA IDA: Inferred from direct assay	33443146	MGI
involved in non-membrane-bounded organelle assembly	IDA IDA: Inferred from direct assay	33443146	MGI
acts upstream of or within recognition of apoptotic cell	IDA IDA: Inferred from direct assay	10811223	MGI
acts upstream of or within recognition of apoptotic cell	IMP IMP: Inferred from mutant phenotype	14645847	MGI
involved in regulation of mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	21300889	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	15345036	MGI
involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	21300889	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	21060799	MGI
located in nucleolus	IDA IDA: Inferred from direct assay	21060799	MGI
located in nucleoplasm	IDA IDA: Inferred from direct assay	21060799	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	33443146	MGI
located in nucleus	IDA IDA: Inferred from direct assay	14729065	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10811223	MGI
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	21060799	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

apoptotic cell clearance receptor PtdSerR	histone arginine demethylase JMJD6
jmjC domain-containing protein 6	jumonji domain-containing protein 6
lysyl-hydroxylase JMJD6	peptide-lysine 5-dioxygenase JMJD6
phosphatidylserine receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139782	SKLB325		99.23%	Unkown
HY-139434	JMJD6-IN-1	Inhibitor	99.69%	Unkown
HY-P10445	TAT-PiET	Inhibitor	/	Unkown
HY-P10446	TAT-PiET-PROTAC	Inhibitor	/	Unkown
HY-RS07039	JMJD6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17009	Jmjd6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23452	Jmjd6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Jmjd6	NCBI	NCBI:23210

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