Lgr4 - leucine-rich repeat-containing G protein-coupled receptor 4 Gene

Mus musculus

Also known as Gpr48; 9130225G07; A330106J01Rik; A930009A08Rik

Gene ID: 107515 | Gene type: protein coding

About Lgr4

Summary

Enables transmembrane signaling receptor activity. Involved in several processes, including metanephros development; regulation of gene expression; and regulation of signal transduction. Acts upstream of or within several processes, including epithelial cell proliferation involved in renal tubule morphogenesis; intestinal stem cell homeostasis; and male genitalia development. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; eye; metanephros; nasal process; and testis. Used to study glaucoma. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human LGR4 (leucine rich repeat containing G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Lgr4 Products(1)

mRNA	Protein	Name
NM_172671.2	NP_766259.2	leucine-rich repeat-containing G-protein coupled receptor 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	21693646	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21693646	MGI
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	21693646	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in bone mineralization	IMP IMP: Inferred from mutant phenotype	19605502	MGI
involved in bone remodeling	IMP IMP: Inferred from mutant phenotype	19605502	MGI
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24353284	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	24353284	MGI
acts upstream of or within digestive tract development	IMP IMP: Inferred from mutant phenotype	24680895	MGI
acts upstream of or within epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16406039	MGI
acts upstream of or within epithelial cell proliferation involved in renal tubule morphogenesis	IGI IGI: Inferred from genetic interaction	24680895	MGI
acts upstream of or within hair follicle development	IGI IGI: Inferred from genetic interaction	24680895	MGI
acts upstream of or within hair follicle development	IMP IMP: Inferred from mutant phenotype	24680895	MGI
acts upstream of or within intestinal stem cell homeostasis	IMP IMP: Inferred from mutant phenotype	24680895	MGI
acts upstream of or within male genitalia development	IMP IMP: Inferred from mutant phenotype	16406039	MGI
involved in metanephric glomerulus development	IMP IMP: Inferred from mutant phenotype	21523854	MGI
involved in metanephric nephron tubule morphogenesis	IMP IMP: Inferred from mutant phenotype	21523854	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	24212090	MGI
involved in negative regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	23589304	MGI
involved in negative regulation of toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23589304	MGI
involved in osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	19605502	MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	21523854	MGI
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	21693646	MGI
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	21727895	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	23393138	MGI
acts upstream of or within tube morphogenesis	IMP IMP: Inferred from mutant phenotype	16406039	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	21693646	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

leucine-rich repeat-containing G-protein coupled receptor 4

G protein-coupled receptor GPR48

G-protein coupled receptor 48

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07618	LGR4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19349	Lgr4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25840	Lgr4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lgr4	NCBI	NCBI:55366

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