2. Gene
  3. Fbxo4 - F-box protein 4 Gene

Fbxo4 - F-box protein 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Fbx4; 1700096C12Rik

Gene ID: 106052 | Gene type: protein coding

About Fbxo4

Summary

Enables ubiquitin protein Ligase activity. Acts upstream of or within several processes, including common myeloid progenitor cell proliferation; positive regulation of protein polyubiquitination; and protein destabilization. Part of SCF ubiquitin Ligase complex. Is expressed in several structures, including craniocervical region bone; esophagus; lung; pituitary gland; and sensory organ. Orthologous to human FBXO4 (F-box protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Fbxo4 Products(1)

mRNA Protein Name
NM_134099.2 NP_598860.2 F-box only protein 4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21242966 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
21911473 MGI
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
29142209 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular homeostasis IMP
IMP: Inferred from mutant phenotype
21911473 MGI
acts upstream of or within cellular response to ionizing radiation IDA
IDA: Inferred from direct assay
21911473 MGI
acts upstream of or within cellular senescence IMP
IMP: Inferred from mutant phenotype
21911473 MGI
acts upstream of or within common myeloid progenitor cell proliferation IMP
IMP: Inferred from mutant phenotype
21911473 MGI
acts upstream of or within negative regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
21911473 MGI
acts upstream of or within negative regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
21911473 MGI
acts upstream of or within positive regulation of protein polyubiquitination IMP
IMP: Inferred from mutant phenotype
21911473 MGI
acts upstream of or within post-transcriptional regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21911473 MGI
acts upstream of or within protein destabilization IMP
IMP: Inferred from mutant phenotype
21911473 MGI
acts upstream of or within regulation of DNA damage checkpoint IMP
IMP: Inferred from mutant phenotype
21911473 MGI
Cellular Component GO Annotation Evidence Reference Source
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
21911473 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-box only protein 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04806 FBXO4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18517 Fbxo4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24999 Fbxo4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fbxo4 NCBI NCBI:26272