Bap1 - Brca1 associated protein 1 Gene

Mus musculus

Also known as uch-x4; mKIAA0272; 2300006C11Rik

Gene ID: 104416 | Gene type: protein coding

About Bap1

Summary

Predicted to enable chromatin binding activity and thiol-dependent Deubiquitinase. Acts upstream of or within several processes, including macrophage homeostasis; regulation of cytokine production involved in inflammatory response; and regulation of inflammatory response. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of PR-DUB complex. Predicted to be active in cytoplasm. Is expressed in gonad; liver; and mammary gland. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in basal cell carcinoma and extrahepatic bile duct adenocarcinoma. Orthologous to human BAP1 (BRCA1 associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Bap1 Products(1)

mRNA	Protein	Name
NM_027088.2	NP_081364.1	ubiquitin carboxyl-terminal hydrolase BAP1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	22878500	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9528852	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	22878500	MGI
involved in common myeloid progenitor cell proliferation	IMP IMP: Inferred from mutant phenotype	22878500	MGI
involved in erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	22878500	MGI
involved in erythrocyte maturation	IMP IMP: Inferred from mutant phenotype	22878500	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	22878500	MGI
involved in granulocyte differentiation	IMP IMP: Inferred from mutant phenotype	22878500	MGI
involved in hematopoietic stem cell homeostasis	IMP IMP: Inferred from mutant phenotype	22878500	MGI
involved in in utero embryonic development	IMP IMP: Inferred from mutant phenotype	22878500	MGI
involved in leukocyte proliferation	IMP IMP: Inferred from mutant phenotype	22878500	MGI
acts upstream of or within macrophage homeostasis	IMP IMP: Inferred from mutant phenotype	26119930	MGI
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	22878500	MGI
involved in myeloid cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22878500	MGI
involved in neuron cellular homeostasis	IMP IMP: Inferred from mutant phenotype	22878500	MGI
involved in neutrophil differentiation	IMP IMP: Inferred from mutant phenotype	22878500	MGI
involved in nucleate erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	22878500	MGI
involved in platelet morphogenesis	IMP IMP: Inferred from mutant phenotype	22878500	MGI
acts upstream of or within regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	26119930	MGI
acts upstream of or within regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	26119930	MGI
involved in thrombocyte differentiation	IMP IMP: Inferred from mutant phenotype	22878500	MGI
involved in tissue homeostasis	IMP IMP: Inferred from mutant phenotype	22878500	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase BAP1

BRCA1-associated protein 1

ubiquitin C-terminal hydrolase X4

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W327122	BAP1-IN-1	Inhibitor	99.86%	Unkown
HY-158774	TG2-179-1	Inducer	≥99.0%	Unkown
HY-169213	LN-439A	Inhibitor	/	Unkown
HY-RS01364	BAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16963	Bap1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23406	Bap1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bap1	NCBI	NCBI:8314

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