2. Gene
  3. Xpo1 - exportin 1 Gene

Xpo1 - exportin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Crm1; Exp1

Gene ID: 103573 | Gene type: protein coding

About Xpo1

Summary

Enables nuclear export signal receptor activity. Acts upstream of or within several processes, including protein export from nucleus; regulation of centrosome duplication; and regulation of protein export from nucleus. Located in nucleus. Is expressed in several structures, including alimentary system; early embryo; nervous system; respiratory system; and sensory organ. Orthologous to human XPO1 (exportin 1). [provided by Alliance of Genome Resources, Apr 2022]

Xpo1 Products(5)

mRNA Protein Name
NM_001035226.1 NP_001030303.1 exportin-1
NM_001412406.1 NP_001399335.1 exportin-1
NM_001412407.1 NP_001399336.1 exportin-1
NM_001412408.1 NP_001399337.1 exportin-1
NM_134014.3 NP_598775.2 exportin-1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables nuclear export signal receptor activity IDA
IDA: Inferred from direct assay
12446771 MGI
enables nuclear export signal receptor activity IMP
IMP: Inferred from mutant phenotype
12446771 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10438867 MGI
Biological Process GO Annotation Evidence Reference Source
involved in mRNA export from nucleus IDA
IDA: Inferred from direct assay
31340148 MGI
involved in mRNA export from nucleus IMP
IMP: Inferred from mutant phenotype
31340148 MGI
acts upstream of or within protein export from nucleus IDA
IDA: Inferred from direct assay
11796723 MGI
involved in protein export from nucleus IDA
IDA: Inferred from direct assay
18606808 MGI
acts upstream of or within protein export from nucleus IMP
IMP: Inferred from mutant phenotype
11092755 MGI
acts upstream of or within protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
16297385 MGI
acts upstream of or within regulation of centrosome duplication IMP
IMP: Inferred from mutant phenotype
16297385 MGI
acts upstream of or within regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
15767664 MGI
acts upstream of or within regulation of protein export from nucleus IMP
IMP: Inferred from mutant phenotype
14981260 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
16297385 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

exportin-1

chromosome region maintenance 1 protein homolog

exportin 1, CRM1 homolog

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-100423 Eltanexor Inhibitor 99.84% Phase 2
HY-15970 Verdinexor 99.94% Phase 1
Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-164710 Biotinylated leptomycin B 99.32% Unkown
HY-RS15889 XPO1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-144763 XPO1-IN-1 Inducer / Unkown
HY-161391 CW0134 Modulator / Unkown
HY-161392 CW2158 Modulator / Unkown
HY-170669 PROTAC XPO1 degrader-1 / Unkown
HY-170671 E3 ligase Ligand 49 / Unkown
HY-170672 XPO1-ligand-1 Ligand / Unkown
HY-170673 E3 Ligase Ligand-linker Conjugate 156 / Unkown
HY-163902 SP100030 analogue 1 Inhibitor / Unkown
HY-RS16700 Xpo1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23134 Xpo1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Xpo1 NCBI NCBI:7514