2. Gene
  3. ADAMTS13 - Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 Gene

ADAMTS13 - Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 102554393 | Gene type: protein coding

About ADAMTS13

Summary

Enables endopeptidase activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and response to potassium ion. Located in extracellular space. Biomarker of cholestasis and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in thrombotic thrombocytopenic purpura. Orthologous to human ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif 13). [provided by Alliance of Genome Resources, Apr 2022]

ADAMTS13 Products(12)

mRNA Protein Name
XM_039106138.1 XP_038962066.1 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X7
XM_039106136.1 XP_038962064.1 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X5
XM_039106131.1 XP_038962059.1 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X2
XM_039106140.1 XP_038962068.1 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X9
XM_039106137.1 XP_038962065.1 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X6
XM_006233879.3 XP_006233941.3 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X1
XM_039106132.1 XP_038962060.1 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X3
XM_039106134.1 XP_038962062.1 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X4
XM_039106133.1 XP_038962061.1 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X4
XM_039106135.1 XP_038962063.1 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X4
XM_039106139.1 XP_038962067.1 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X8
XM_039106141.1 XP_038962069.1 A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X10
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
19652891 RGD
enables peptidase activity IDA
IDA: Inferred from direct assay
16689760 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to interleukin-4 IEP
IEP: Inferred from expression pattern
18433458 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
22871409 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
18433458 RGD
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
18433458 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
19652891 RGD
involved in response to amine IEP
IEP: Inferred from expression pattern
17383642 RGD
involved in response to interleukin-4 IEP
IEP: Inferred from expression pattern
18433458 RGD
involved in response to potassium ion IEP
IEP: Inferred from expression pattern
17804457 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
16689760 RGD
involved in response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
18433458 RGD
involved in response to type II interferon IEP
IEP: Inferred from expression pattern
18433458 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
19652891 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 13

A disintegrin and metalloproteinase with thrombospondin motifs 13-like

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13

a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 mot

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P5354 FRETS-VWF73 / Unkown
HY-RS00294 ADAMTS13 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17864 Adamts13 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24333 Adamts13 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ADAMTS13 NCBI NCBI:11093