Acacb - acetyl-Coenzyme A carboxylase beta Gene

Mus musculus

Also known as Acc2; Accb

Gene ID: 100705 | Gene type: protein coding

About Acacb

Summary

Enables Acetyl-CoA Carboxylase activity. Involved in several processes, including energy homeostasis; malonyl-CoA biosynthetic process; and negative regulation of fatty acid beta-oxidation. Acts upstream of or within fatty acid biosynthetic process. Located in mitochondrion. Is expressed in axial skeleton; cranium; and liver. Orthologous to human ACACB (Acetyl-CoA Carboxylase beta). [provided by Alliance of Genome Resources, Apr 2022]

Acacb Products(4)

mRNA	Protein	Name
NM_001403527.1	NP_001390456.1	acetyl-CoA carboxylase 2 isoform 1 precursor
NM_001403528.1	NP_001390457.1	acetyl-CoA carboxylase 2 isoform 3
NM_001403529.1	NP_001390458.1	acetyl-CoA carboxylase 2 isoform 4
NM_133904.3	NP_598665.2	acetyl-CoA carboxylase 2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetyl-CoA carboxylase activity	IDA IDA: Inferred from direct assay	17210641	MGI
enables acetyl-CoA carboxylase activity	IMP IMP: Inferred from mutant phenotype	17210641	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	12920182	MGI
acts upstream of or within fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	17210641	MGI
involved in malonyl-CoA biosynthetic process	IMP IMP: Inferred from mutant phenotype	18487439	MGI
involved in negative regulation of fatty acid beta-oxidation	IMP IMP: Inferred from mutant phenotype	12920182	MGI
involved in negative regulation of fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	11283375	MGI
involved in negative regulation of lipid catabolic process	IMP IMP: Inferred from mutant phenotype	15677334	MGI
involved in positive regulation of heart growth	IMP IMP: Inferred from mutant phenotype	18487439	MGI
involved in positive regulation of lipid storage	IMP IMP: Inferred from mutant phenotype	11283375	MGI
involved in regulation of glucose metabolic process	IMP IMP: Inferred from mutant phenotype	15677334	MGI
involved in response to nutrient levels	IMP IMP: Inferred from mutant phenotype	12920182	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	10677481	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

acetyl-CoA carboxylase 2

ACC-beta

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00122	ACACB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20357	Acacb Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26866	Acacb Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Acacb	NCBI	NCBI:32

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