2. Gene
  3. MICA - MHC class I polypeptide-related sequence A Gene

MICA - MHC class I polypeptide-related sequence A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as MIC-A; PERB11.1

Gene ID: 100507436 | Gene type: protein coding

About MICA

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,400,711-31,415,315 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 407 orthologues and 22 paralogues. Ubiquitous expression in lung (RPKM 8.7), endometrium (RPKM 7.4) and 25 other tissues.

Summary

This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related Antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]

MICA Products(5)

mRNA Protein Name
NM_000247.3 NP_000238.1 MHC class I polypeptide-related sequence A isoform 1 (MICA*001) precursor
NM_001177519.3 NP_001170990.1 MHC class I polypeptide-related sequence A isoform 2 (MICA*00801) precursor
NM_001289152.2 NP_001276081.1 MHC class I polypeptide-related sequence A isoform 3 (MICA*00801)
NM_001289153.2 NP_001276082.1 MHC class I polypeptide-related sequence A isoform 3 (MICA*00801)
NM_001289154.2 NP_001276083.1 MHC class I polypeptide-related sequence A isoform 4 (MICA*00801)
Protein Preferred Names Protein Names

MHC class I polypeptide-related sequence A

HLA class I antigen

Recombinant MICA Proteins

Cat. No. Product Name Accession Purity
HY-P70157 MICA Protein, Human (285a.a, HEK293, His) AAH16929.1 (E24-Q308) ≥95%
HY-P70579 MICA Protein, Human (HEK293, Fc) AAH16929.1 (E24-Q308) ≥95%
HY-P77997 MICA Protein, Human (HEK293, His-Avi) Q96QC4 (E24-Q308) ≥95%
HY-P77998 MICA Protein, Human (Biotinylated, HEK293, His-Avi) Q96QC4 (E24-Q308) ≥95%
HY-P700790 MICA Protein, Human (HEK293, mFc) NP_001276081.1 (R105-S200) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-155311 NKG2D-IN-1 / Unkown
HY-155312 NKG2D-IN-2 / Unkown
HY-RS08424 MICA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-151782 H-(Gly)3-Lys(N3)-OH / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MICA RGD RGD:1311714
Macaca fascicularis MICA NCBI
Mus musculus MICA NCBI