2. Gene
  3. FBXW7 - Fbxw7 F-box and WD repeat domain containing 7 Gene

FBXW7 - Fbxw7 F-box and WD repeat domain containing 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Fbw7

Gene ID: 100360914 | Gene type: protein coding

About FBXW7

Summary

Predicted to enable several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin ligase-substrate adaptor activity. Predicted to be involved in several processes, including cellular protein metabolic process; positive regulation of cellular protein metabolic process; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity; protein destabilization; and vasculogenesis. Predicted to be located in several cellular components, including Golgi apparatus; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be part of Parkin-FBXW7-Cul1 ubiquitin Ligase complex and SCF ubiquitin Ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]

FBXW7 Products(9)

mRNA Protein Name
XM_039103741.1 XP_038959669.1 F-box/WD repeat-containing protein 7 isoform X2
XM_039103743.1 XP_038959671.1 F-box/WD repeat-containing protein 7 isoform X2
XM_039103739.1 XP_038959667.1 F-box/WD repeat-containing protein 7 isoform X2
XM_039103742.1 XP_038959670.1 F-box/WD repeat-containing protein 7 isoform X2
XM_039103740.1 XP_038959668.1 F-box/WD repeat-containing protein 7 isoform X2
XM_039103744.1 XP_038959672.1 F-box/WD repeat-containing protein 7 isoform X2
XM_039103738.1 XP_038959666.1 F-box/WD repeat-containing protein 7 isoform X1
XM_006232555.4 XP_006232617.1 F-box/WD repeat-containing protein 7 isoform X4
XM_003749311.5 XP_003749359.1 F-box/WD repeat-containing protein 7 isoform X3
Protein Preferred Names Protein Names

F-box/WD repeat-containing protein 7

F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase

F-box and WD-40 domain protein 7

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04818 FBXW7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-173082 10-SLF Degrader / Unkown
HY-RS17548 Fbxw7 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24007 Fbxw7 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens FBXW7 NCBI NCBI:55294