2. Gene
  3. H6pd - hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) Gene

H6pd - hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Gpd1; G6pd1; Gpd-1

Gene ID: 100198 | Gene type: protein coding

About H6pd

Summary

Enables 6-phosphogluconolactonase activity and glucose-6-phosphate dehydrogenase activity. Involved in regulation of cortisol biosynthetic process. Acts upstream of or within pentose-phosphate shunt. Located in sarcoplasmic reticulum. Is expressed in alimentary system; cranium; facial bone primordium; liver; and tooth. Human ortholog(s) of this gene implicated in cortisone reductase deficiency; cortisone reductase deficiency 1; and multiple sclerosis. Orthologous to human H6PD (hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

H6pd Products(2)

mRNA Protein Name
NM_001291004.1 NP_001277933.1 GDH/6PGL endoplasmic bifunctional protein isoform 2 precursor
NM_173371.4 NP_775547.2 GDH/6PGL endoplasmic bifunctional protein isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 6-phosphogluconolactonase activity IDA
IDA: Inferred from direct assay
12831846 MGI
enables glucose-6-phosphate dehydrogenase activity IDA
IDA: Inferred from direct assay
12831846 MGI
enables glucose-6-phosphate dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
18222920 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within pentose-phosphate shunt IDA
IDA: Inferred from direct assay
12831846 MGI
involved in regulation of cortisol biosynthetic process IMP
IMP: Inferred from mutant phenotype
16356929 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
18222920 MGI
is active in sarcoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
18222920 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GDH/6PGL endoplasmic bifunctional protein

glucose 1-dehydrogenase

glucose-6-phosphate dehydrogenase 1

Related Agents

Approval
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10617A Rucaparib Inhibitor 99.97% Unkown
HY-10617 Rucaparib phosphate Inhibitor 99.76% Yes
HY-102003 Rucaparib monocamsylate Inhibitor 99.91% Yes
HY-102003A Rucaparib camsylate Inhibitor / Unkown
HY-10617C Rucaparib tartrate Inhibitor / Unkown
HY-10617B Rucaparib hydrochloride Inhibitor / Unkown
HY-10617D Rucaparib acetate Inhibitor / Unkown
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05980 H6PD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-10617AS Rucaparib-d8 Inhibitor / Unkown
HY-RS17126 H6pd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23571 H6pd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens H6pd NCBI NCBI:9563