ROCK1 - Rho associated coiled-coil containing protein kinase 1 Gene

Oryctolagus cuniculus

Also known as ROCK-I

Gene ID: 100009220 | Gene type: protein coding

About ROCK1

Chromosome 9: 62,279,345-62,423,146 reverse strand.OryCun2.0:CM000798.1

This gene has 2 transcripts (splice variants), 212 orthologues and 5 paralogues.

mRNA	Protein	Name
NM_001082367.1	NP_001075836.1	rho-associated protein kinase 1

STKc_ROCK1

SbcC

HR1_ROCK1

ROCK_SBD

Rho_Binding

ROCK_SBD

PH_ROCK

C1_ROCK1

Protein Preferred Names

Protein Names

rho-associated protein kinase 1

HEBM1	cAMP-dependent protein kinase ROCK-I
cePKA	corneal epithelial Rho-associated-Ser/Thr kinase 1
p160 ROCK-1	p160ROCK
rho-associated, coiled-coil-containing protein kinase 1	rho-associated, coiled-coil-containing protein kinase I

Approval

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10071	Y-27632	Inhibitor	99.97%	Unkown
HY-10583	Y-27632 dihydrochloride	Inhibitor	99.98%	Unkown
HY-10341	Fasudil Hydrochloride	Inhibitor	99.96%	Yes
HY-15307	Belumosudil	Inhibitor	99.77%	Yes
HY-15685	Ripasudil	Inhibitor	99.92%	Unkown
HY-13911	Hydroxyfasudil	Inhibitor	98.42%	Unkown
HY-15307A	Belumosudil mesylate	Inhibitor	99.89%	Yes
HY-13911A	Hydroxyfasudil hydrochloride	Inhibitor	98.88%	Unkown
HY-10341A	Fasudil	Inhibitor	/	Unkown
HY-10341C	Fasudil dihydrochloride	Inhibitor	/	Unkown
HY-10341B	Fasudil hydrochloride semihydrate	Inhibitor	/	Unkown
HY-15685A	Ripasudil free base	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109191	Sovesudil	Inhibitor	98.31%	Phase 3
HY-109191A	Sovesudil hydrochloride	Inhibitor	99.79%	Phase 3
HY-15687A	SAR407899	Inhibitor	99.60%	Phase 2
HY-15687	SAR407899 hydrochloride	Inhibitor	98.66%	Phase 2
HY-16071	AT13148	Inhibitor	99.21%	Phase 1

Pre-clinical Phase

Bioactive Molecules (27)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15392	Chroman 1	Inhibitor	99.38%	Unkown
HY-15556	GSK269962A	Inhibitor	99.83%	Unkown
HY-11000	GSK429286A	Inhibitor	98.15%	Unkown
HY-119937	ROCK inhibitor-2	Inhibitor	99.87%	Unkown
HY-18990	GSK180736A	Inhibitor	98.01%	Unkown
HY-15755	RKI-1447	Inhibitor	98.29%	Unkown
HY-13300	SR-3677	Inhibitor	99.90%	Unkown
HY-12437	BDP5290	Inhibitor	98.80%	Unkown
HY-14362	GSK-25	Inhibitor	99.68%	Unkown
HY-108518	SB-772077B dihydrochloride	Inhibitor	≥99.0%	Unkown
HY-100270	Rho-Kinase-IN-1	Inhibitor	99.91%	Unkown
HY-16758	Verosudil	Inhibitor	99.18%	Unkown
HY-10319	BAY-549	Inhibitor	99.46%	Unkown
HY-126275	HSD1590	Inhibitor	99.54%	Unkown
HY-110339	RKI-1447 dihydrochloride	Inhibitor	98.04%	Unkown
HY-15392A	Chroman 1 dihydrochloride	Inhibitor	99.11%	Unkown
HY-149266	THK01	Inhibitor	99.80%	Unkown
HY-14227	LIMK-IN-1	Inhibitor	99.33%	Unkown
HY-107209	RKI-1313	Inhibitor	≥98.0%	Unkown
HY-132302A	Hu7691 free base	Inhibitor	/	Unkown
HY-132302	Hu7691	Inhibitor	/	Unkown
HY-16758A	Verosudil hydrochloride	Inhibitor	/	Unkown
HY-15556A	GSK269962A hydrochloride	Inhibitor	/	Unkown
HY-125221	DJ4	Inhibitor	98.48%	Unkown
HY-162596	NRL-1049	Inhibitor	/	Unkown
HY-13300A	SR-3677 dihydrochloride	Inhibitor	/	Unkown
HY-122011	PF-4950834	Inhibitor	/	Unkown

Species	Symbol	Source	ID
Homo sapiens	ROCK1	NCBI	NCBI:6093

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