2. Cell Cycle/DNA Damage
  3. Eukaryotic Initiation Factor (eIF)
  4. GCN2 activator-1

GCN2 activator-1 (Compound 20) is a GCN2 activator. GCN2 activator-1 binds within the ATP-pocket of GCN2 and activates GCN2 in a GCN1-independent manner. GCN2 activator-1 activates Integrated Stress Response (ISR) in cells. GCN2 activator-1 inhibits PKR with an IC50 of 3.75 µM. GCN2 activator-1 can be used for research of pulmonary veno-occlusive disease (PVOD).

For research use only. We do not sell to patients.

GCN2 activator-1

GCN2 activator-1 Chemical Structure

CAS No. : 315705-10-3

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GCN2 activator-1 Related Antibodies

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Description

GCN2 activator-1 (Compound 20) is a GCN2 activator. GCN2 activator-1 binds within the ATP-pocket of GCN2 and activates GCN2 in a GCN1-independent manner. GCN2 activator-1 activates Integrated Stress Response (ISR) in cells. GCN2 activator-1 inhibits PKR with an IC50 of 3.75 µM. GCN2 activator-1 can be used for research of pulmonary veno-occlusive disease (PVOD)[1].

IC50 & Target[1]

EIF2AK2/PKR

3.75 μM (IC50)

Molecular Weight

290.37

Formula

C11H10N6S2
CAS No.
SMILES

NC1=NC(C)=C(C2=CSC(NC3=NC=CC=N3)=N2)S1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GCN2 activator-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GCN2 activator-1315705-10-3Eukaryotic Initiation Factor (eIF)PVODGCN2GCN1EIF2AK4Inhibitorinhibitorinhibit

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