2. Anti-infection
  3. CHIKV
  4. GAP-1173149

GAP-1173149 is a Chikungunya Virus polymerase inhibitor targeting the CHIKV nsP4 RNA-dependent RNA polymerase.

For research use only. We do not sell to patients.

GAP-1173149

GAP-1173149 Chemical Structure

CAS No. : 1622645-58-2

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GAP-1173149 Related Antibodies

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Description

GAP-1173149 is a Chikungunya Virus polymerase inhibitor targeting the CHIKV nsP4 RNA-dependent RNA polymerase[1].

In Vitro

GAP-1173149 shows EC50 values of 15.6, 18.6, 5.3 and 11.62 μM in U-2 OS cells, Vero cells, CHIKV replicon and normal human dermal fibroblasts[1].
GAP-1173149 shows CC50 values >100 μM in U-2 OS and Vero cells, and >500 μM in normal human dermal fibroblasts[1].
GAP-1173149 (100 μM) exhibits alphavirus-specific activity, inhibiting RNA replication of CHIKV, o’nyong-nyong virus (ONNV), Ross River virus (RRV), Eastern equine encephalitis virus (EEEV) and Barmah Forest virus (BFV), while showing no inhibition on unrelated viruses (HPIV3, RSV, SARS-CoV-2, VSV) or Sindbis virus (SINV)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GAP-1173149 Related Antibodies
Molecular Weight

305.33

Formula

C14H19N5O3
CAS No.
SMILES

O=C(NCC1=NNC2=C1CCCCC2)CN(C(NC3)=O)C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GAP-1173149 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GAP-11731491622645-58-2GAP1173149GAP 1173149CHIKVChikungunya virusChikungunya Virus PolymeraseRNA polymerasensP4U-2 OSVeroo’nyong-nyong virus (ONNV)Ross River virus (RRV)Eastern equine encephalitis virus (EEEV)Barmah Forest virus (BFV)Inhibitorinhibitorinhibit

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GAP-1173149
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HY-178334
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