2. Others Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug Derivative ADC Payload Topoisomerase
  4. Fmoc-Val-Cit-PAB-Exatecan

Fmoc-Val-Cit-PAB-Exatecan is a precursor form of Exatecan (HY-13631). Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.

For research use only. We do not sell to patients.

Fmoc-Val-Cit-PAB-Exatecan

Fmoc-Val-Cit-PAB-Exatecan Chemical Structure

CAS No. : 2754384-69-3

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Fmoc-Val-Cit-PAB-Exatecan Related Antibodies

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Topoisomerase Topo I Topo II

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Description

Fmoc-Val-Cit-PAB-Exatecan is a precursor form of Exatecan (HY-13631). Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1].

IC50 & Target[1]

Topoisomerase I

 

Molecular Weight

1063.13

Formula

C58H59FN8O11
CAS No.
SMILES

FC(C=C(N=C1C2=CC3=C4COC([C@](CC)3O)=O)C5=C6CC[C@H](NC(OCC7=CC=C(NC([C@@H](NC([C@@H](NC(OCC8C9=CC=CC=C9C%10=CC=CC=C%108)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C7)=O)C5=C1CN2C4=O)=C6C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Fmoc-Val-Cit-PAB-Exatecan Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-Val-Cit-PAB-Exatecan2754384-69-3Drug DerivativeADC PayloadTopoisomeraseDrug derivativeADC CytotoxinExatecantopoisomerase ICancerstereoisomerInhibitorinhibitorinhibit

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