2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Fmoc-D-Trp(Boc)-OH

Fmoc-D-Trp(Boc)-OH is a cleavable ADC linker that used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Fmoc-D-Trp(Boc)-OH Chemical Structure

Fmoc-D-Trp(Boc)-OH Chemical Structure

CAS No. : 163619-04-3

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Based on 1 publication(s) in Google Scholar

Fmoc-D-Trp(Boc)-OH Related Antibodies

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Description

Fmoc-D-Trp(Boc)-OH is a cleavable ADC linker that used in the synthesis of antibody-drug conjugates (ADCs).

IC50 & Target

Cleavable
In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fmoc-D-Trp(Boc)-OH Related Antibodies
Molecular Weight

526.58

Formula

C31H30N2O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@H](NC(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)=O)CC4=CN(C(OC(C)(C)C)=O)C5=C4C=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (189.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8990 mL 9.4952 mL 18.9905 mL
5 mM 0.3798 mL 1.8990 mL 3.7981 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.74%

SDS (393 KB)

COA (262 KB) HNMR (136 KB) RP-HPLC (240 KB) LCMS (110 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8990 mL 9.4952 mL 18.9905 mL 47.4762 mL
5 mM 0.3798 mL 1.8990 mL 3.7981 mL 9.4952 mL
10 mM 0.1899 mL 0.9495 mL 1.8990 mL 4.7476 mL
15 mM 0.1266 mL 0.6330 mL 1.2660 mL 3.1651 mL
20 mM 0.0950 mL 0.4748 mL 0.9495 mL 2.3738 mL
25 mM 0.0760 mL 0.3798 mL 0.7596 mL 1.8990 mL
30 mM 0.0633 mL 0.3165 mL 0.6330 mL 1.5825 mL
40 mM 0.0475 mL 0.2374 mL 0.4748 mL 1.1869 mL
50 mM 0.0380 mL 0.1899 mL 0.3798 mL 0.9495 mL
60 mM 0.0317 mL 0.1583 mL 0.3165 mL 0.7913 mL
80 mM 0.0237 mL 0.1187 mL 0.2374 mL 0.5935 mL
100 mM 0.0190 mL 0.0950 mL 0.1899 mL 0.4748 mL
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Fmoc-D-Trp(Boc)-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-D-Trp(Boc)-OH163619-04-3ADC LinkerAntibody-drug conjugates linkerADCantibody-drugconjugatescleavableInhibitorinhibitorinhibit

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