2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Ferroptosis Reactive Oxygen Species (ROS)
  4. Ferroptosis inducer-12

Ferroptosis inducer-12 is a potent and selective ferroptosis inducer. Ferroptosis inducer-12 exhibits potent antiproliferative activity against HT1080 and OS-RC-2, with IC50 values of 3 nM and 5 nM, respectively. Ferroptosis inducer-12 strongly inhibits GPX4 enzymatic activity, induces intracellular ROS and elevates intracellular Fe2+ levels in OS-RC-2 cells. Ferroptosis inducer-12 significantly inhibits tumor growth in BALB/c nude mice bearing OS-RC-2 xenografts. Ferroptosis inducer-12 can be used for the study of cancer.

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Ferroptosis inducer-12

Ferroptosis inducer-12 Chemical Structure

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Ferroptosis inducer-12 Related Antibodies

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Description

Ferroptosis inducer-12 is a potent and selective ferroptosis inducer. Ferroptosis inducer-12 exhibits potent antiproliferative activity against HT1080 and OS-RC-2, with IC50 values of 3 nM and 5 nM, respectively. Ferroptosis inducer-12 strongly inhibits GPX4 enzymatic activity, induces intracellular ROS and elevates intracellular Fe2+ levels in OS-RC-2 cells. Ferroptosis inducer-12 significantly inhibits tumor growth in BALB/c nude mice bearing OS-RC-2 xenografts. Ferroptosis inducer-12 can be used for the study of cancer[1].

In Vitro

Ferroptosis inducer-12 (Compound A6) (48 h) exhibits potent antiproliferative activity against HT1080 and OS-RC-2, with IC50 values of 3 nM (HT1080) and 5 nM (OS-RC-2)[1].
Ferroptosis inducer-12 (1 μM, 2 h) strongly inhibits glutathione peroxidase 4 (GPX4) enzymatic activity in OS-RC-2 cells[1].
Ferroptosis inducer-12 (0.5 μM, 4 h) induces intracellular ROS, elevates intracellular Fe2+ levels and promotes lipid peroxidation (LPO) accumulation in OS-RC-2 cells[1].
Ferroptosis inducer-12 (10 nM, 24 h) significantly suppresses migration and reduces invasive capacity of OS-RC-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ferroptosis inducer-12 Related Antibodies

Cell Migration Assay [1]

Cell Line: OS-RC-2 cells
Concentration: 10 nM
Incubation Time: 24 h
Result: Suppressed migration of OS-RC-2 cells.

Cell Invasion Assay[1]

Cell Line: OS-RC-2 cells
Concentration: 10 nM
Incubation Time: 24 h
Result: Reduced invasive capacity of OS-RC-2 cells.
In Vivo

Ferroptosis inducer-12 (Compound A6) (25-50 mg/kg, i.p., once every 3 days for 27 days) significantly inhibits tumor growth in BALB/c nude mice bearing OS-RC-2 xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: OS-RC-2 cells (2 × 106 in 100 μL PBS) were subcutaneously implanted into the right limb subcutaneous fat of 4-week-old male BALB/c nude mice (weight: 14-16 g)[1]
Dosage: 25 mg/kg, 50 mg/kg
Administration: i.p., once every 3 days for 27 days
Result: Showed tumor growth inhibition rate of 44.59% at 50 mg/kg, and reduced tumor volume and weight.
Caused no obvious histological damage to major organs (heart, liver, spleen, lung, kidney) in BALB/c nude mice.
Molecular Weight

599.46

Formula

C34H29FeN3O4
SMILES

O=C(C#C)N([C@@H](C(OC)=O)C1)[C@@H](C2=CC=C(C(NCc3cccc3)=O)C=C2)C4=C1C5=CC=CC=C5N4.[][Fe][].c6cccc6
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ferroptosis inducer-12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferroptosis inducer-12Ferroptosis inducer12Ferroptosis inducer 12FerroptosisReactive Oxygen Species (ROS)CancerferroptosisHT1080OS-RC-2ROSInhibitorinhibitorinhibit

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