2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. 5-HT Receptor Cytochrome P450
  4. Escholtzine

Escholtzine is an alkaloid found in Eschscholzia californica. Escholtzine can inhibit [3H]8-OH-DPAT Binding to the 5-HT1A receptor with an EC50 of 11 μM and a Ki of 6 μM. Escholtzine can inhibit CYP3A4 with an IC50 of 13.4 μg/mL. Escholtzine can be used for the research of neurological disease, such as anxiety.

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Escholtzine

Escholtzine Chemical Structure

CAS No. : 4040-75-9

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Escholtzine Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Description

Escholtzine is an alkaloid found in Eschscholzia californica. Escholtzine can inhibit [3H]8-OH-DPAT Binding to the 5-HT1A receptor with an EC50 of 11 μM and a Ki of 6 μM. Escholtzine can inhibit CYP3A4 with an IC50 of 13.4 μg/mL. Escholtzine can be used for the research of neurological disease, such as anxiety[1].

IC50 & Target[1]

5-HT1A Receptor

11 μM (EC50)

5-HT1A Receptor

6 μM (Ki)

CYP3A4

13.4 μg/mL (IC50)

Molecular Weight

323.34

Formula

C19H17NO4
CAS No.
SMILES

[H][C@]1(N2C)CC3=CC4=C(OCO4)C=C3[C@]2([H])CC5=CC6=C(OCO6)C=C51
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Escholtzine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Escholtzine4040-75-95-HT ReceptorCytochrome P450Serotonin Receptor5-hydroxytryptamine ReceptorCYPsAlkaloidEschscholzia californica5-HT1ACYP3A4neurological diseaseanxietyInhibitorinhibitorinhibit

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