Eritadenine  (Synonyms: Lentinacin; D-Eritadenine; Lentysine)

Eritadenine (D-Eritadenine) is a potent AdoHcyase inhibitor, with an IC₅₀ value of 7 nM. Eritadenine is also an acyclic sugar adenosine analogue. Eritadenine exhibits an inhibitory effect on the growth of Cryptosporidium parvum, with a MIC₅₀ of 3 μM. Eritadenine can be used in the research of colorectal adenocarcinoma^[1][2].

SAHH^[1][2].

D-Eritadenine (IC₅₀ = 7 nM) exerts a potent inhibitory effect on S-adenosylhomocysteine hydrolase (AdoHcyase)^[1].
D-Eritadenine (MIC₅₀ = 3 μM) exhibits a inhibitory effect on the growth of Cryptosporidium parvum^[2].
D-Eritadenine (1 mM; 48 h) shows low cytotoxicity to uninfected HCT-8 cells, with a cell viability rate of 80%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

253.21

C₉H₁₁N₅O₄

23918-98-1

Solid

White to off-white

O=C([C@@H]([C@@H](CN1C=NC2=C(N=CN=C12)N)O)O)O

Room temperature in continental US; may vary elsewhere.

• [1]. Huang Y, et al. Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine. J Biol Chem. 2002 Mar 1;277(9):7477-82.  [Content Brief]

  [2]. Ctrnáctá V, et al. Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro. Exp Parasitol. 2010 Oct;126(2):113-6.  [Content Brief]