2. Vitamin D Related/Nuclear Receptor
  3. Progesterone Receptor
  4. EIDD-1723

EIDD-1723 is a Progesterone (HY-N0437) analogues, that binds progesterone receptor (PR) with an IC50 of 2.25 μM. EIDD-1723 is the prodrug of EIDD-036 (HY-17649). EIDD-1723 may exert its neuroprotective effects not solely through progesterone receptor (PR)-dependent pathways but also via non-genomic mechanisms, such as modulation of inflammatory responses and oxidative stress. EIDD-1723 can be used for the study of traumatic brain injury (TBI).

For research use only. We do not sell to patients.

EIDD-1723

EIDD-1723 Chemical Structure

CAS No. : 1659302-89-2

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

EIDD-1723 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

EIDD-1723 is a Progesterone (HY-N0437) analogues, that binds progesterone receptor (PR) with an IC50 of 2.25 μM. EIDD-1723 is the prodrug of EIDD-036 (HY-17649). EIDD-1723 may exert its neuroprotective effects not solely through progesterone receptor (PR)-dependent pathways but also via non-genomic mechanisms, such as modulation of inflammatory responses and oxidative stress. EIDD-1723 can be used for the study of traumatic brain injury (TBI)[1][2][3].

In Vitro

ANT308 (1-10 μM, 48 h) significantly enhances CD69 and Ki67 expressions in CD4+ and CD8+ T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EIDD-1723 Related Antibodies
Parmacokinetics[2]
Species Dose Route Indicator value
Rat 10 mg/kg i.m. Cmax 1362 ng/mL
Rat 2 mg/kg i.v. Cmax 182 ng/mL
Rat 10 mg/kg i.m. AUClast 724 ng·h/mL
Rat 2 mg/kg i.v. AUClast 48 ng·h/mL
In Vivo

EIDD-1723 (3-30 mg/kg, i.m., 2 mg/kg, i.v., 30 mg/kg, p.o., single dose) after administered by intramuscular injection rapidly and completely transforms into the active metabolite EIDD-036, which is capable of crossing the blood-brain barrier[1][3].
EIDD-1723 (10 mg/kg, i.m., for 9 doses) significantly reduces cerebral edema and improved recovery from motor, sensory and spatial learning deficits in rats[1][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: TBI model induced by controlled cortical impact (CCI) established in male SD rats weighing 200-350 g[1][3]
Dosage: 10 mg/kg
Administration: Intramuscular injection (i.m.), at 1, 6, and 24 h and 2, 3, 4, 5, 6, and 7 days post-injury
Result: Significantly reduced cerebral edema, improved motor function, shortened the delay time of sensory neglect, and enhanced spatial learning ability.
Significantly reduced brain tissue damage and weakened the activation of astrocytes and microglia cells.
Molecular Weight

483.45

Formula

C22H32NNa2O6P
CAS No.
SMILES

C[C@@]12[C@](CC[C@@H]2/C(C)=N/OCOP(O[Na])(O[Na])=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(CC3)=CC(CC4)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

EIDD-1723 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EIDD-17231659302-89-2EIDD1723EIDD 1723Progesterone ReceptorNR3C3Traumatic brain injuryNeurosteroidProgesteroneProgesterone analogsEdemaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
EIDD-1723
Cat. No.:
HY-125547
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.