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  4. Ebsulfur

Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase (TryR) of Trypanosoma brucei, with IC50 values of 61-293 nM for Trypanosoma brucei. Ebsulfur can be used for the research of African trypanosomiasis.

For research use only. We do not sell to patients.

Ebsulfur Chemical Structure

Ebsulfur Chemical Structure

CAS No. : 2527-03-9

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Based on 1 publication(s) in Google Scholar

Ebsulfur Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • Biological Activity

  • Purity & Documentation

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Description

Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase (TryR) of Trypanosoma brucei, with IC50 values of 61-293 nM for Trypanosoma brucei. Ebsulfur can be used for the research of African trypanosomiasis[1].

Cellular Effect
Cell Line Type Value Description References
Vero C1008 CC50
19.43 μM
Compound: 1.1
Cytotoxicity against monkey Vero C1008 cells after 72 hrs by MTT assay
Cytotoxicity against monkey Vero C1008 cells after 72 hrs by MTT assay
[PMID: 28159413]
Molecular Weight

227.28

Formula

C13H9NOS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC=CC=C2)SC3=C1C=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (274.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3999 mL 21.9993 mL 43.9986 mL
5 mM 0.8800 mL 4.3999 mL 8.7997 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

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C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3999 mL 21.9993 mL 43.9986 mL 109.9965 mL
5 mM 0.8800 mL 4.3999 mL 8.7997 mL 21.9993 mL
10 mM 0.4400 mL 2.1999 mL 4.3999 mL 10.9996 mL
15 mM 0.2933 mL 1.4666 mL 2.9332 mL 7.3331 mL
20 mM 0.2200 mL 1.1000 mL 2.1999 mL 5.4998 mL
25 mM 0.1760 mL 0.8800 mL 1.7599 mL 4.3999 mL
30 mM 0.1467 mL 0.7333 mL 1.4666 mL 3.6665 mL
40 mM 0.1100 mL 0.5500 mL 1.1000 mL 2.7499 mL
50 mM 0.0880 mL 0.4400 mL 0.8800 mL 2.1999 mL
60 mM 0.0733 mL 0.3667 mL 0.7333 mL 1.8333 mL
80 mM 0.0550 mL 0.2750 mL 0.5500 mL 1.3750 mL
100 mM 0.0440 mL 0.2200 mL 0.4400 mL 1.1000 mL
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Ebsulfur Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ebsulfur2527-03-9ParasiteTrypanosoma bruceibenzisothiazolone cytocidalAfrican trypanosomiasisInhibitorinhibitorinhibit

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