2. Metabolic Enzyme/Protease
  3. Glutaminase
  4. Duazomycin sodium

Duazomycin sodium  (Synonyms: Duazomycin A sodium)

Cat. No.: HY-105723A Purity: 99.11%
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Duazomycin (Duazomycin A) sodium is a glutamine antagonist. Duazomycin sodium can significantly enhance the effectiveness of 6-Mercaptopurine (6-MP) (HY-13677) in experimental allergic encephalomyelitis (EAE) without increasing toxicity.

For research use only. We do not sell to patients.

Duazomycin sodium

Duazomycin sodium Chemical Structure

CAS No. : 2839447-07-1

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Based on 1 publication(s) in Google Scholar

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Description

Duazomycin (Duazomycin A) sodium is a glutamine antagonist. Duazomycin sodium can significantly enhance the effectiveness of 6-Mercaptopurine (6-MP) (HY-13677) in experimental allergic encephalomyelitis (EAE) without increasing toxicity[1][2].

Molecular Weight

235.17

Formula

C8H10N3NaO4
CAS No.
Appearance

Oil

Color

Light yellow to yellow

SMILES

[N-]=[N+]=CC(CC[C@@H](C(O[Na])=O)NC(C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (212.61 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2522 mL 21.2612 mL 42.5224 mL
5 mM 0.8504 mL 4.2522 mL 8.5045 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.2522 mL 21.2612 mL 42.5224 mL 106.3061 mL
5 mM 0.8504 mL 4.2522 mL 8.5045 mL 21.2612 mL
10 mM 0.4252 mL 2.1261 mL 4.2522 mL 10.6306 mL
15 mM 0.2835 mL 1.4174 mL 2.8348 mL 7.0871 mL
20 mM 0.2126 mL 1.0631 mL 2.1261 mL 5.3153 mL
25 mM 0.1701 mL 0.8504 mL 1.7009 mL 4.2522 mL
30 mM 0.1417 mL 0.7087 mL 1.4174 mL 3.5435 mL
40 mM 0.1063 mL 0.5315 mL 1.0631 mL 2.6577 mL
50 mM 0.0850 mL 0.4252 mL 0.8504 mL 2.1261 mL
60 mM 0.0709 mL 0.3544 mL 0.7087 mL 1.7718 mL
80 mM 0.0532 mL 0.2658 mL 0.5315 mL 1.3288 mL
100 mM 0.0425 mL 0.2126 mL 0.4252 mL 1.0631 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Duazomycin sodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Duazomycin2839447-07-1Duazomycin AGlutaminaseExperimental allergic encephalomelitis (EAE)Inhibitorinhibitorinhibit

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