2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Droxidopa

Droxidopa  (Synonyms: L-DOPS; DOPS; SM5688)

Cat. No.: HY-13458 Purity: 98.38%
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Handling Instructions Technical Support

Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder).

For research use only. We do not sell to patients.

Droxidopa Chemical Structure

Droxidopa Chemical Structure

CAS No. : 23651-95-8

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Based on 1 publication(s) in Google Scholar

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Droxidopa Related Antibodies

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Description

Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder)[1][2][3][4].

In Vivo

Droxidopa (200 mg/kg;i.p.) alters dopamine neuron and prefrontal cortex activity and improves attention-deficit/hyperactivity disorder-like behaviors in rats[2]. Droxidopa (10, 20 mg/kg; i.p.) significantly increases the paw withdrawal latency and inhibits mechanical hypersensitivity to thermal stimulation in 6-OHDA-lesioned rats at the 5th week after surgery[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 250-380g male Sprague-Dawley rats[2]
Dosage: 200 mg/kg (10 mg/kg, i.p. benserazide was given to the animals at 20 or 30 min prior to L-DOPS injection)
Administration: I.p.
Result: Significantly decreased hyperactivity of BZ-pretreated SHR/NCrl at 30 (P < 0.01) and 40 min (P < 0.05) post-injection, improved inattention-like behavior of SHR/NCrl, and ameliorated impulsive-like behavior of SHR/NCrl and Wistar rats.
Clinical Trial
Molecular Weight

213.19

Formula

C9H11NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(O)C=CC([C@@H](O)[C@@H](C(O)=O)N)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 21.74 mg/mL (101.97 mM; ultrasonic and warming and adjust pH to 3 with 1 M HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6907 mL 23.4533 mL 46.9065 mL
5 mM 0.9381 mL 4.6907 mL 9.3813 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.38%

SDS (393 KB)

COA (232 KB) LCMS (103 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6907 mL 23.4533 mL 46.9065 mL 117.2663 mL
5 mM 0.9381 mL 4.6907 mL 9.3813 mL 23.4533 mL
10 mM 0.4691 mL 2.3453 mL 4.6907 mL 11.7266 mL
15 mM 0.3127 mL 1.5636 mL 3.1271 mL 7.8178 mL
20 mM 0.2345 mL 1.1727 mL 2.3453 mL 5.8633 mL
25 mM 0.1876 mL 0.9381 mL 1.8763 mL 4.6907 mL
30 mM 0.1564 mL 0.7818 mL 1.5636 mL 3.9089 mL
40 mM 0.1173 mL 0.5863 mL 1.1727 mL 2.9317 mL
50 mM 0.0938 mL 0.4691 mL 0.9381 mL 2.3453 mL
60 mM 0.0782 mL 0.3909 mL 0.7818 mL 1.9544 mL
80 mM 0.0586 mL 0.2932 mL 0.5863 mL 1.4658 mL
100 mM 0.0469 mL 0.2345 mL 0.4691 mL 1.1727 mL
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Droxidopa Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Droxidopa23651-95-8L-DOPS DOPS SM5688SM5688SM 5688SM-5688Adrenergic ReceptorBeta Receptororally activeblood pressureneurogenic orthostatic hypotensionADHDInhibitorinhibitorinhibit

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