2. Antibody-drug Conjugate/ADC Related Anti-infection Cell Cycle/DNA Damage PI3K/Akt/mTOR Epigenetics Apoptosis Autophagy
  3. ADC Cytotoxin Antibiotic Bacterial Topoisomerase AMPK HIV HBV Apoptosis Autophagy Mitophagy
  4. Dox-btn2

Dox-btn2 is a biotinylated derivative of Doxorubicin (HY-15142A), with a biotin label at the point of conjugation to doxorubicin at 3'-NH2. Dox-btn2 can be used for cell imaging. While Doxorubicin is mainly accumulated in the nucleus, while Dox-btn2 is mainly located in the cytoplasm.

For research use only. We do not sell to patients.

Dox-btn2 Chemical Structure

Dox-btn2 Chemical Structure

CAS No. : 3026061-31-1

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Based on 1 publication(s) in Google Scholar

Dox-btn2 Related Antibodies

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HIV HIV-1 HIV-2

  • Biological Activity

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Description

Dox-btn2 is a biotinylated derivative of Doxorubicin (HY-15142A), with a biotin label at the point of conjugation to doxorubicin at 3'-NH2. Dox-btn2 can be used for cell imaging. While Doxorubicin is mainly accumulated in the nucleus, while Dox-btn2 is mainly located in the cytoplasm[1].

In Vitro

Dox-btn2 (1 μM; 6 h; Exc=531/40 nm and Emi=593/40 nm) exhibits visualization in U2OS cells, helps in situ mapping with Chem-map of small-molecule interactions with DNA and chromatin proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dox-btn2 Related Antibodies
Molecular Weight

1017.10

Formula

C48H64N4O18S
CAS No.
Appearance

Solid

Color

Brown to orange

SMILES

O=C1C2=C(O)C3=C([C@H](C[C@](C(CO)=O)(C3)O)O[C@H]4C[C@H](NC(CCOCCOCCOCCOCCNC(CCCC[C@H]5[C@@]6([H])NC(N[C@]6(CS5)[H])=O)=O)=O)[C@H](O)[C@H](C)O4)C(O)=C2C(C7=C1C=CC=C7OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (49.16 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9832 mL 4.9159 mL 9.8319 mL
5 mM 0.1966 mL 0.9832 mL 1.9664 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9832 mL 4.9159 mL 9.8319 mL 24.5797 mL
5 mM 0.1966 mL 0.9832 mL 1.9664 mL 4.9159 mL
10 mM 0.0983 mL 0.4916 mL 0.9832 mL 2.4580 mL
15 mM 0.0655 mL 0.3277 mL 0.6555 mL 1.6386 mL
20 mM 0.0492 mL 0.2458 mL 0.4916 mL 1.2290 mL
25 mM 0.0393 mL 0.1966 mL 0.3933 mL 0.9832 mL
30 mM 0.0328 mL 0.1639 mL 0.3277 mL 0.8193 mL
40 mM 0.0246 mL 0.1229 mL 0.2458 mL 0.6145 mL
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Dox-btn2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dox-btn23026061-31-1ADC CytotoxinAntibioticBacterialTopoisomeraseAMPKHIVHBVApoptosisAutophagyMitophagyADC PayloadAMP-activated protein kinaseHuman immunodeficiency virusHepatitis B virusMitochondrial Autophagy3'-NH2cell imagingnucleuscytoplasmvisualizationInhibitorinhibitorinhibit

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