2. Others MAPK/ERK Pathway Autophagy
  3. Reference Standards p38 MAPK Raf Autophagy
  4. Doramapimod (Standard)

Doramapimod (Standard)  (Synonyms: BIRB 796 (Standard))

Cat. No.: HY-10320R
Handling Instructions Technical Support

Doramapimod (Standard) is the analytical standard of Doramapimod. This product is intended for research and analytical applications. Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod has picomolar affinity for p38 kinase (Kd=0.1 nM). Doramapimod also inhibits B-Raf with an IC50 of 83 nM.

For research use only. We do not sell to patients.

Doramapimod (Standard)

Doramapimod (Standard) Chemical Structure

CAS No. : 285983-48-4

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5 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
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50 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
100 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
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Information
Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

527.66

Formula

C31H37N5O3
CAS No.
SMILES

O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=C4C=CC=CC4=C(OCCN5CCOCC5)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Doramapimod (Standard) Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Doramapimod (Standard)285983-48-4BIRB 796 (Standard)Reference Standardsp38 MAPKRafAutophagyRaf kinasesInhibitorinhibitorinhibit

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