2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. DEL1187-126-5-80

DEL1187-126-5-80 is a JAK3 inhibitor with IC50s of 52 and 7.9 nM against JAK3 WT in 0 and 60 min. DEL1187-126-5-80 has no activity at all towards the C909S mutant, JAK1, JAK2, and TYK2. DEL1187-126-5-80 can be used for the study of immune-mediated diseases.

For research use only. We do not sell to patients.

DEL1187-126-5-80

DEL1187-126-5-80 Chemical Structure

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DEL1187-126-5-80 Related Antibodies

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Description

DEL1187-126-5-80 is a JAK3 inhibitor with IC50s of 52 and 7.9 nM against JAK3 WT in 0 and 60 min. DEL1187-126-5-80 has no activity at all towards the C909S mutant, JAK1, JAK2, and TYK2. DEL1187-126-5-80 can be used for the study of immune-mediated diseases[1].

IC50 & Target[1]

JAK3

7.9 nM (IC50)

Molecular Weight

407.47

Formula

C21H25N7O2
SMILES

C#CC(NCC1CCCN(C1)C2=NC(NC3=CC=C(C=C3)CC(NC)=O)=NC=N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DEL1187-126-5-80 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DEL1187-126-5-80JAKJanus kinaseDNA-encoded libraryJAK3Covalent warheadCovalent inhibitorSelectivityInhibitorinhibitorinhibit

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