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  4. DBCO-amine

DBCO-amine (GMP) is a GMP grade DBCO-amine (HY-W000423). DBCO-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. DBCO-amine is used in the synthesis of antibody-drug conjugates (ADCs).

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DBCO-amine

DBCO-amine Chemical Structure

CAS No. : 1255942-06-3

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Based on 1 publication(s) in Google Scholar

DBCO-amine Related Antibodies

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Description

DBCO-amine (GMP) is a GMP grade DBCO-amine (HY-W000423). DBCO-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. DBCO-amine is used in the synthesis of antibody-drug conjugates (ADCs)[1].

In Vitro

Click chemistry is used to describe the selective, modular, wide range and high-yield chemical reactions that allow rapid synthesis of new compounds through heteroatom linking (C-X-C). Bertozzi developed click chemistry in a new dimension—Bioorthogonal chemistry. It is defined as a rapid and selective reaction that does not interfere with biological processes under physiological conditions. Common reaction structures of click chemistry, such as Azide, Alkyne, DBCO, BCN, TCO and Tetrazine.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DBCO-amine Related Antibodies
Molecular Weight

276.33

Formula

C18H16N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCN
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DBCO-amine Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBCO-amine (GMP)1255942-06-3Biochemical Assay Reagentsnon-cleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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HY-W000423G
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