2. Others Protein Tyrosine Kinase/RTK Autophagy Apoptosis
  3. Reference Standards Bcr-Abl Src Autophagy Apoptosis
  4. Dasatinib hydrochloride (Standard)

Dasatinib hydrochloride (Standard)  (Synonyms: BMS-354825 hydrochloride (Standard))

Cat. No.: HY-10181AR Purity: ≥98%
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Dasatinib (hydrochloride) (Standard) is the analytical standard of Dasatinib (hydrochloride). This product is intended for research and analytical applications. Dasatinib (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively. Dasatinib hydrochloride also induces apoptosis and autophagy.

For research use only. We do not sell to patients.

Dasatinib hydrochloride (Standard) Chemical Structure

Dasatinib hydrochloride (Standard) Chemical Structure

CAS No. : 854001-07-3

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Description

Dasatinib (hydrochloride) (Standard) is the analytical standard of Dasatinib (hydrochloride). This product is intended for research and analytical applications. Dasatinib (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively. Dasatinib hydrochloride also induces apoptosis and autophagy.

Molecular Weight

524.47

Formula

C22H27Cl2N7O2S
CAS No.
SMILES

O=C(C1=CN=C(S1)NC2=NC(C)=NC(N3CCN(CC3)CCO)=C2)NC4=C(C=CC=C4Cl)C.[H]Cl
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Dasatinib hydrochloride (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dasatinib hydrochloride (Standard)854001-07-3BMS-354825 hydrochloride (Standard)Reference StandardsBcr-AblSrcAutophagyApoptosisorallyactiveantitumorantiproliferativeK562CMLPC3prostateMDA-MB-231breastWiDrcolonInhibitorinhibitorinhibit

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