2. Others Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Membrane Transporter/Ion Channel PI3K/Akt/mTOR
  3. Reference Standards Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite
  4. D-α-Hydroxyglutaric acid disodium (Standard)

D-α-Hydroxyglutaric acid disodium (Standard)  (Synonyms: Disodium (R)-2-hydroxyglutarate (Standard))

Cat. No.: HY-100542R
Handling Instructions Technical Support

D-α-Hydroxyglutaric acid (disodium) (Standard) is the analytical standard of D-α-Hydroxyglutaric acid (disodium). This product is intended for research and analytical applications. D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling.

For research use only. We do not sell to patients.

D-α-Hydroxyglutaric acid disodium (Standard)

D-α-Hydroxyglutaric acid disodium (Standard) Chemical Structure

CAS No. : 103404-90-6

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Information
Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

192.08

Formula

C5H6Na2O5
CAS No.
SMILES

O=C(O[Na])[C@H](O)CCC(O[Na])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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D-α-Hydroxyglutaric acid disodium (Standard) Related Classifications

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Keywords:

D-α-Hydroxyglutaric acid disodium (Standard)103404-90-6Disodium (R)-2-hydroxyglutarate (Standard)Reference StandardsReactive Oxygen Species (ROS)ATP SynthasemTOREndogenous MetaboliteMammalian target of RapamycinCeKDM7Aα-ketoglutarateH3K9me2H3K27me2competitorIDH1IDH25-methlycytosineexcitotoxicneurotoxicInhibitorinhibitorinhibit

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