(D-Pro7)-Angiotensin I/II (1-7)

Cat. No.: HY-P1656: Data Sheet Handling Instructions
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(D-Pro7)-Angiotensin I/II (1-7) is a selective, peptide-based antagonist of Angiotensin-(1-7). (D-Pro7)-Angiotensin I/II (1-7) potently blocks multiple biological effects of Ang-(1-7). (D-Pro7)-Angiotensin I/II (1-7) inhibits the hypertensive response induced by microinjection of Ang-(1-7) into the rostral ventrolateral medulla (RVLM) and abolishes the endothelium-dependent vasorelaxation of mouse. (D-Pro7)-Angiotensin I/II (1-7) can be used for the study of cardiovascular diseases.

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(D-Pro7)-Angiotensin I/II (1-7) Chemical Structure

CAS No. : 586962-44-9

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Description	(D-Pro7)-Angiotensin I/II (1-7) is a selective, peptide-based antagonist of Angiotensin-(1-7). (D-Pro7)-Angiotensin I/II (1-7) potently blocks multiple biological effects of Ang-(1-7). (D-Pro7)-Angiotensin I/II (1-7) inhibits the hypertensive response induced by microinjection of Ang-(1-7) into the rostral ventrolateral medulla (RVLM) and abolishes the endothelium-dependent vasorelaxation of mouse. (D-Pro7)-Angiotensin I/II (1-7) can be used for the study of cardiovascular diseases^[1].
Molecular Weight	899.00
Formula	C₄₁H₆₂N₁₂O₁₁
CAS No.	586962-44-9
Sequence	Asp-Arg-Val-Tyr-Ile-His-{d-Pro}
Sequence Shortening	DRVYIH-{d-Pro}
SMILES	OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CN=CN2)C(N3[C@H](CCC3)C(O)=O)=O)=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (257 KB) Handling Instructions (2659 KB)
References	[1]. Santos RA, et al. Characterization of a new selective antagonist for angiotensin-(1-7), D-pro7-angiotensin-(1-7). Hypertension. 2003 Mar;41(3 Pt 2):737-43. [Content Brief]