CI-1040 hydrochloride (Synonyms: PD 184352 hydrochloride)

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CI-1040 (PD 184352) hydrochloride is an orally active, highly specific inhibitor of MEK, with an IC₅₀ of 17 nM for MEK1.

For research use only. We do not sell to patients.

CI-1040 hydrochloride Chemical Structure

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Other In-stock Forms of CI-1040 hydrochloride:

CI-1040

Other Forms of CI-1040 hydrochloride:

CI-1040 In-stock

22 Publications Citing Use of MCE CI-1040 hydrochloride

: CI-1040 hydrochloride purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2023 Apr 6;211:115542. [Abstract]; CI-1040 (PD 184352; 10, 20, 40 nM; 48 h) significantly inhibits the expression of iNOS and COX2 in a dose-dependent manner in ATDC5 cells.

: CI-1040 hydrochloride purchased from MedChemExpress. Usage Cited in: Neurotox Res. 2017 Nov;32(4):535-543. [Abstract]; Lithium promotes autophagy flux by activating MEK/ERK pathway in cells. Original Western blot showing LC3-II and p62 abundance following treatment with lithium in the presence of PD184352 and SCH772984 in neurons. Arithmetic means±SEM (n=5) showing LC3-II abundance following treatment with lithium in the presence of PD184352 and SCH772984 in neurons.

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Purity & Documentation
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Description

CI-1040 (PD 184352) hydrochloride is an orally active, highly specific inhibitor of MEK, with an IC₅₀ of 17 nM for MEK1^[1]^[2]^[3].

IC₅₀ & Target

MEK1

Molecular Weight

515.12

Synonyms

PD 184352 hydrochloride

Formula

C₁₇H₁₅Cl₂F₂IN₂O₂

SMILES

O=C(C1=CC=C(C(F)=C1NC2=CC=C(I)C=C2Cl)F)NOCC3CC3.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Allen LF, et al. CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK). Semin Oncol. 2003 Oct;30(5 Suppl 16):105-16. [Content Brief]

[2]. Wei CR, et al. MEK inhibitor CI-1040 induces apoptosis in acute myeloid leukemia cells in vitro. Eur Rev Med Pharmacol Sci. 2016 May;20(10):1961-8. [Content Brief] [Content Brief]

[3]. Kramer BW, et al. Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040strongly reduces growth and improves lung structure. BMC Cancer. 2004 Jun 1;4:24. [Content Brief]

CI-1040 hydrochloride Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CI-1040PD 184352CI1040CI 1040PD184352PD-184352MEKApoptosisMitogen-activated protein kinase kinaseMAPKKMAP2KInhibitorinhibitorinhibit

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