Cholicamideβ 

Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis^[1].

Cholicamideβ (compound 6) (4-16 μM; 22 h) induces apoptosis and necrosis in RAW264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cholicamideβ (compound 6) (100 μg/mouse; tested after 16 h and 21 d) shows low toxicity and increases HA-specific IgG antibody titers in C57BL/6 mice immunized with split influenza vaccine^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

879.34

C₅₅H₉₄N₂O₆

3036578-71-6

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhuo SH, et al. Identification of a Self-Assembling Small-Molecule Cancer Vaccine Adjuvant with an Improved Toxicity Profile. J Med Chem. 2023 Sep 7.. .  [Content Brief]