CHF 4227 free base

Name: CHF 4227 free base
Brand: MedChemExpress
SKU: HY-107045
Rating: 4.5 (1 reviews)

Cat. No.: HY-107045: Data Sheet Handling Instructions
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CHF 4227 free base is an orally active and selective estrogen receptor modulator (SERM) with high affinity to the human estrogen receptor-α and -β (K_i values of 0.017 nM and 0.099 nM, respectively).

For research use only. We do not sell to patients.

CHF 4227 free base Chemical Structure

CAS No. : 444643-64-5

Size	Stock	Quantity
1 mg	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Proteins:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

hERα

0.017 nM (Ki)

hERβ

0.099 nM (Ki)

In Vivo

In immature rats, oral administration of CHF 4227 free base for 3 days inhibited the uterotrophic action of Ethinylestradiol (EE2) (HY-B0216) (ED₅₀DMBA (HY-W011845)-induced mammary tumors, the incidence being reduced from 87.5 to 26.3% 6 months after DMBA administration^[1].
In ovariectomized (OVX) rats treated orally for 4 weeks, CHF 4227 free basecompletely inhibits OVX effects on bone density (ED₅₀[1].
CHF 4227 free base reduces serum cholesterol (ED₅₀[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

471.59

Formula

C₃₀H₃₃NO₄

CAS No.

444643-64-5

SMILES

OC1=CC=C2C(CC3=CC=C(OCCN4CCCCC4)C=C3)=C(C5=CC=C(OC)C=C5)COC2=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Elisabetta Galbiati, et al. Pharmacological actions of a novel, potent, tissue-selective benzopyran estrogen. J Pharmacol Exp Ther. 2002 Oct;303(1):196-203. [Content Brief]

[2]. Maurizio Civelli, et al. Single and multiple ascending dose studies of a novel tissue-selective oestrogen receptor modulator, CHF 4227, in healthy postmenopausal women. Br J Clin Pharmacol. 2007 Sep;64(3):304-16. [Content Brief]