Cefquinome 

Cefquinome is a broad-spectrum cephem antibiotic that has inhibitory effects on a variety of Gram-positive and Gram-negative bacteria, including Staphylococci, Streptococci, Pseudomonas, and Enterobacteriaceae^[1][2][3].

Cefquinome binds to penicillin-binding proteins (PBPs), thereby inhibiting the synthesis of bacterial cell walls^[3].
Cefquinome inhibits methicillin susceptible S. aureus, Streptococcus spp., Enterococci, E. coli, Salmonella spp., Klebsiella spp., S. marcescens, Enterobacter spp., Citrobacter spp., P. mirabilis, Indole-positive Proteus spp., P. aeruginosa with MICs of 0.006-6.25 μg/mL^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefquinome (12.5 mg/kg, tail vein injection, single dose) exhibits anti-infectious activity against Klebsiella pneumoniae in rats pneumonia model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

528.60

C₂₃H₂₄N₆O₅S₂

84957-30-2

O=C1[C@@H](NC(/C(C2=CSC(N)=N2)=N\OC)=O)[C@@]3([H])SCC(C[N+]4=C5CCCCC5=CC=C4)=C(C([O-])=O)N13

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chin NX, et al. In vitro activity of cefquinome, a new cephalosporin, compared with other cephalosporin antibiotics. Diagn Microbiol Infect Dis. 1992 May-Jun;15(4):331-7.  [Content Brief]

  [2]. Qu S, et al., Cefquinome-loaded microsphere formulations against Klebsiella pneumonia infection during experimental infections. Drug Deliv. 2018 Nov;25(1):909-915.  [Content Brief]

  [3]. Limbert M, et al., Antibacterial activities in vitro and in vivo and pharmacokinetics of cefquinome (HR 111V), a new broad-spectrum cephalosporin. Antimicrob Agents Chemother. 1991 Jan;35(1):14-9.  [Content Brief]