2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
  4. CE-355621

CE-355621 is a humanized anti-c-Met IgG1 monoclonal antibody. CE-355621 can effectively bind with human c-Met (KD = 200 pM, IC50 = 466 pM) in A549 cells and cyno c-Met (KD = 610 pM) in cynomolgus kidney cells. CE-355621 inhibits the c-Met signaling pathway by blocking HGF binding. CE-355621 significantly inhibit the growth of tumors dependent on the c-Met/HGF pathway. CE-355621 can be used for research on cancer such as glioblastoma and gastric cancer.

For research use only. We do not sell to patients.

CE-355621 Chemical Structure

CE-355621 Chemical Structure

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Description

CE-355621 is a humanized anti-c-Met IgG1 monoclonal antibody. CE-355621 can effectively bind with human c-Met (KD = 200 pM, IC50 = 466 pM) in A549 cells and cyno c-Met (KD = 610 pM) in cynomolgus kidney cells. CE-355621 inhibits the c-Met signaling pathway by blocking HGF binding. CE-355621 significantly inhibit the growth of tumors dependent on the c-Met/HGF pathway. CE-355621 can be used for research on cancer such as glioblastoma and gastric cancer[1][2].

IC50 & Target[1][2]

c-Met

 

In Vitro

CE-355621 (0.01-100 nM, 4 h) can efficiently block the binding of c-Met to HGF and induce c-Met degradation in A549 cells[1].
CE-355621 (0.01 nM-10 nM, 24 h) significantly inhibits c-Met activation in U87MG cells[1].
CE-355621 (0.01-10 μg/mL, 48 h) can induce c-Met degradation in U87MG cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CE-355621 Related Antibodies

Western Blot Analysis[1]

Cell Line: U87MG cells
Concentration: 0.01 nM-10 nM
Incubation Time: 24 h
Result: Significantly inhibited activation of c-Met.

Western Blot Analysis[1]

Cell Line: U87MG cells
Concentration: 0.01-10 μg/mL
Incubation Time: 48 h
Result: Reduced the level of c-Met.
In Vivo

CE-355621 (25-200 μg, i.p., on day 0, 2, 3, 6 and 8) significantly delays tumor growth in female CD-1 nu/nu mice bearing U87MG xenografts[1].
CE-355621 (400 μg, i.p., on day 7 and 14) significantly inhibits tumor growth in female CD-1 nu/nu mice bearing GTL-16 xenografts[1].
CE-355621 (200 μg, i.p., single dose, on day 7) can effectively inhibit tumor volume growth and uptake of 18F-FDG in female nude (nu/nu) mice bearing U87MG xenografts[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5×106 U87MG cells injected female CD-1 nu/nu mice[1]
Dosage: 25, 100 and 200 μg
Administration: Intraperitoneal injection (i.p.) on day 0, 2, 3, 6 and 8
Result: Significantly delayed tumor growth (up to 22.3 days) and inhibited 80 % of c-Met phosphorylation.
Animal Model: 1.0-5.0×106 GTL-16 cells injected female CD-1 nu/nu mice[1]
Dosage: 400 μg
Administration: Intraperitoneal injection (i.p.) on day 7 and 14
Result: Inhibited tumor growth by 85% and reduced c-Met phosphorylation by 48%
Animal Model: 1×106 U87MG cells injected female nude (nu/nu) mice[2]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.), single dose on day 7
Result: Significantly inhibited tumor volume.
Significantly reduced uptake of 18F-FDG.
Gene ID

4233  [NCBI]

Accession
Target

HGFR/c-Met
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

N/A
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CE-355621 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CE-355621CE355621CE 355621c-Met/HGFRc-MetHGFU87MGGTL-16antitumorInhibitorinhibitorinhibit

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