2. GPCR/G Protein
  3. LPL Receptor
  4. CAY10444

CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca2+ in HeLa cells expressing S1P3 receptors.

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CAY10444

CAY10444 Chemical Structure

CAS No. : 298186-80-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
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Based on 4 publication(s) in Google Scholar

CAY10444 Related Antibodies

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Description

CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca2+ in HeLa cells expressing S1P3 receptors[1].

IC50 & Target[1]

S1PR3

 

In Vitro

BML-241 inhibits increases in intracellular Ca2+ concentration via P2 receptor or α1A-adrenoceptor stimulation and α1A-adrenoceptor-mediated contraction of rat mesenteric artery, while it does not affect S1P3-mediated decrease of Forskolin-induced cyclic AMP accumulation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAY10444 Related Antibodies
Molecular Weight

287.46

Formula

C15H29NO2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@H]1NC(SC1)CCCCCCCCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (34.79 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4787 mL 17.3937 mL 34.7874 mL
5 mM 0.6957 mL 3.4787 mL 6.9575 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.0%

SDS (393 KB)

COA (241 KB) HNMR (249 KB) MS (179 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4787 mL 17.3937 mL 34.7874 mL 86.9686 mL
5 mM 0.6957 mL 3.4787 mL 6.9575 mL 17.3937 mL
10 mM 0.3479 mL 1.7394 mL 3.4787 mL 8.6969 mL
15 mM 0.2319 mL 1.1596 mL 2.3192 mL 5.7979 mL
20 mM 0.1739 mL 0.8697 mL 1.7394 mL 4.3484 mL
25 mM 0.1391 mL 0.6957 mL 1.3915 mL 3.4787 mL
30 mM 0.1160 mL 0.5798 mL 1.1596 mL 2.8990 mL
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CAY10444 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAY10444298186-80-8BML-241CAY 10444CAY-10444BML241BML 241LPL ReceptorLysophospholipid ReceptorS1P3 antagonistS1P3 receptorsCa2+ concentrationInhibitorinhibitorinhibit

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