2. GPCR/G Protein Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Angiotensin Receptor PPAR
  4. Candesartan

Candesartan (GMP) (CV 11974 (GMP)) is Candesartan (HY-B0205) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI).

For research use only. We do not sell to patients.

Candesartan Chemical Structure

Candesartan Chemical Structure

CAS No. : 139481-59-7

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Description

Candesartan (GMP) (CV 11974 (GMP)) is Candesartan (HY-B0205) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI)[1][2][3].

In Vivo

Candesartan (GMP) (i.p.; 1 mg/kg/day; continuously for 1, 3 or 28 dpi) has neuroprotective effect, reducing neuronal injury, decreasing lesion volume and microglial activation, protecting CBF and improving functional behavior in a mouse model of TBI[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (nine-week-old, male, 22-28 g)[3]
Dosage: 1 mg/kg
Administration: i.p.; 1 mg/kg/day; continuously for 1, 3 or 28 dpi.
Result: Reduced the lesion volume after CCI injury by approximately 50%, decreased the number of dying neurons, lessened the number of activated microglial cells, protected cerebral blood flow (CBF), and reduced the expression of the cytokine TGFß1 while increasing expression of TGFB3.
Showed good motor skills on the rotarod 3 days after injury, and improved performance in the Morris water maze 4 weeks after injury.
Clinical Trial
Molecular Weight

440.45

Formula

C24H20N6O3
CAS No.
SMILES

O=C(C1=C2C(N=C(OCC)N2CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)=CC=C1)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Candesartan Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Candesartan (GMP)139481-59-7CV 11974 (GMP)Angiotensin ReceptorPPARPeroxisome proliferator-activated receptorsoralangiotensin II AT1-ReceptorPPAR-γantihypertensivehypertensionhronic heart failure (CHF)Traumatic brain injury (TBI)Inhibitorinhibitorinhibit

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