2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. BVT.13

BVT.13 is an orally active and selective PPARγ agonist with a maximal efficacy similar to that of Rosiglitazone (HY-17386). In addition, BVT.13 exhibits antidiabetic activity in ob/ob mice.

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BVT.13

BVT.13 Chemical Structure

CAS No. : 756813-87-3

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BVT.13 Related Antibodies

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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Description

BVT.13 is an orally active and selective PPARγ agonist with a maximal efficacy similar to that of Rosiglitazone (HY-17386). In addition, BVT.13 exhibits antidiabetic activity in ob/ob mice[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
1.3 μM
Compound: 6, BVT.13
Activity at human PPARgamma transfected in HEK293 cells assessed as transactivation activity by luciferase reporter gene assay
Activity at human PPARgamma transfected in HEK293 cells assessed as transactivation activity by luciferase reporter gene assay
[PMID: 25734377]
Molecular Weight

404.20

Formula

C18H11Cl2N3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC(OC2=NC=CC=N2)=CC=C1NC(C3=CC=C(Cl)C=C3Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4.17 mg/mL (10.32 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4740 mL 12.3701 mL 24.7402 mL
5 mM 0.4948 mL 2.4740 mL 4.9480 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4740 mL 12.3701 mL 24.7402 mL 61.8506 mL
5 mM 0.4948 mL 2.4740 mL 4.9480 mL 12.3701 mL
10 mM 0.2474 mL 1.2370 mL 2.4740 mL 6.1851 mL
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BVT.13 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BVT.13756813-87-3PPARPeroxisome proliferator-activated receptorsOrally activeagonistantidiabeticob/ob miceInhibitorinhibitorinhibit

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BVT.13
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