2. MAPK/ERK Pathway
  3. Raf
  4. Brimarafenibum

Brimarafenibum  (Synonyms: Brimarafenib)

Cat. No.: HY-159508 Purity: 99.35%
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Brimarafenibum (Brimarafenib) is a rapidly accelerated fibrosarcoma (Raf) kinase inhibitor, wtih antineoplastic effect.

For research use only. We do not sell to patients.

Brimarafenibum Chemical Structure

Brimarafenibum Chemical Structure

CAS No. : 1643326-82-2

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Based on 1 publication(s) in Google Scholar

Brimarafenibum Related Antibodies

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Description

Brimarafenibum (Brimarafenib) is a rapidly accelerated fibrosarcoma (Raf) kinase inhibitor, wtih antineoplastic effect[1].

Molecular Weight

482.41

Formula

C24H17F3N4O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(C=C(C(F)=C1)F)=C1NC(N[C@H]2[C@@]3([H])[C@]2([H])OC4=CC=C(OC5=C6C(NC=C5)=NC(CC6)=O)C=C43)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (69.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0729 mL 10.3646 mL 20.7293 mL
5 mM 0.4146 mL 2.0729 mL 4.1459 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0729 mL 10.3646 mL 20.7293 mL 51.8231 mL
5 mM 0.4146 mL 2.0729 mL 4.1459 mL 10.3646 mL
10 mM 0.2073 mL 1.0365 mL 2.0729 mL 5.1823 mL
15 mM 0.1382 mL 0.6910 mL 1.3820 mL 3.4549 mL
20 mM 0.1036 mL 0.5182 mL 1.0365 mL 2.5912 mL
25 mM 0.0829 mL 0.4146 mL 0.8292 mL 2.0729 mL
30 mM 0.0691 mL 0.3455 mL 0.6910 mL 1.7274 mL
40 mM 0.0518 mL 0.2591 mL 0.5182 mL 1.2956 mL
50 mM 0.0415 mL 0.2073 mL 0.4146 mL 1.0365 mL
60 mM 0.0345 mL 0.1727 mL 0.3455 mL 0.8637 mL
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Brimarafenibum Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Brimarafenibum1643326-82-2BrimarafenibRafRaf kinasesInhibitorinhibitorinhibit

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