2. Protein Tyrosine Kinase/RTK
  3. IGF-1R
  4. BMS-577098

BMS-577098 is an orally active and ATP-competitive insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 0.016 μM. BMS-577098 shows anti-tumor effect.

For research use only. We do not sell to patients.

BMS-577098

BMS-577098 Chemical Structure

CAS No. : 667402-44-0

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BMS-577098 Related Antibodies

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Description

BMS-577098 is an orally active and ATP-competitive insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 0.016 μM. BMS-577098 shows anti-tumor effect[1].

In Vivo

BMS-577098 (Compound 27) (20 mg/kg, p.o., daily for 21 days) shows anti-tumor effect in Colo205 and RD1 xenograft mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

537.05

Formula

C28H33ClN6O3
CAS No.
SMILES

COCCN(CC1)CCN1C2=CC(C)=C(N=C(C3=C(NC[C@@H](O)C4=CC=CC(Cl)=C4)C=CNC3=O)N5)C5=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BMS-577098 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-577098667402-44-0BMS577098BMS 577098IGF-1RInsulin-like growth factor-1 receptorcancertumorColo205RD1Inhibitorinhibitorinhibit

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