2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. BG48

BG48 is a potent HDAC inhibitor. BG48 inhibits the enzymatic activity of HDAC1 and HDAC2.

For research use only. We do not sell to patients.

BG48

BG48 Chemical Structure

CAS No. : 1628784-53-1

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BG48 Related Antibodies

Top Publications Citing Use of Products

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

BG48 is a potent HDAC inhibitor. BG48 inhibits the enzymatic activity of HDAC1 and HDAC2[1].

IC50 & Target[1]

HDAC1

 

HDAC2

 

Molecular Weight

441.55

Formula

C25H23N5OS
CAS No.
Appearance

Solid

SMILES

O=C(C1=CC=C(C=C1)/N=N/C2=CC=C(N(C)C)C=C2)NC3=C(N)C=CC(C4=CC=CS4)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (226.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2647 mL 11.3237 mL 22.6475 mL
5 mM 0.4529 mL 2.2647 mL 4.5295 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2647 mL 11.3237 mL 22.6475 mL 56.6187 mL
5 mM 0.4529 mL 2.2647 mL 4.5295 mL 11.3237 mL
10 mM 0.2265 mL 1.1324 mL 2.2647 mL 5.6619 mL
15 mM 0.1510 mL 0.7549 mL 1.5098 mL 3.7746 mL
20 mM 0.1132 mL 0.5662 mL 1.1324 mL 2.8309 mL
25 mM 0.0906 mL 0.4529 mL 0.9059 mL 2.2647 mL
30 mM 0.0755 mL 0.3775 mL 0.7549 mL 1.8873 mL
40 mM 0.0566 mL 0.2831 mL 0.5662 mL 1.4155 mL
50 mM 0.0453 mL 0.2265 mL 0.4529 mL 1.1324 mL
60 mM 0.0377 mL 0.1887 mL 0.3775 mL 0.9436 mL
80 mM 0.0283 mL 0.1415 mL 0.2831 mL 0.7077 mL
100 mM 0.0226 mL 0.1132 mL 0.2265 mL 0.5662 mL
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BG48 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BG481628784-53-1BG 48BG-48HDACHistone deacetylasesMCF-7 cellsChemo-Optical Modulation of Epigenetically-regulated Transcription’ (COMET)Inhibitorinhibitorinhibit

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