Benzo-18-crown-6-ether  (Synonyms: B18C6)

Benzo-18-crown-6-ether (B18C6) is a crown ether compound. Benzo-18-crown-6-ether can be applied to the research of biological materials, analytical chemistry and other fields^[1][2].

Benzo-18-crown-6-ether has a binding constant of log K_b=1.63 with ammonium ions in a methanol-water mixed solvent^[1].
Benzo-18-crown-6-ether, whose cavity size is slightly larger than the diameter of calcium ions, can be synthesized into a resin through phenol polycondensation reaction, and is used in chromatography to study the adsorption selectivity and isotope effects of calcium ions. It exhibits good adsorption capacity for calcium ions in 9 M hydrochloric acid solution, with a separation coefficient of 1.9×10^-3 for the ⁴⁰Ca/⁴⁸Ca isotope pair^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

312.36

C₁₆H₂₄O₆

14098-24-9

Solid

White to yellow

C1=CC=C2C(=C1)OCCOCCOCCOCCOCCO2

Room temperature in continental US; may vary elsewhere.

• [1]. Ehala S, et al. Application of affinity capillary electrophoresis and density functional theory to the investigation of benzo-18-crown-6-ether complex with ammonium cation. J Chromatogr A. 2009 Nov 6;1216(45):7927-31.  [Content Brief]

  [2]. Hayasaka K, et al. Calcium ion selectivity and isotope effects studied by using benzo-18-crown-6 resins. Progress in Nuclear Energy, 2008, 50(2-6): 510-513.